The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis
Background: Nonalcoholic fatty liver disease is considered to be the hepatic component of metabolic syndrome (MetS). However, the association between changes in MetS status and the risk of liver cirrhosis (LC) has not been investigated to date. This study assessed the association between changes in...
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MDPI AG
2021-12-01
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1948 |
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| author | Goh-Eun Chung Young Chang Yuri Cho Eun-Ju Cho Jeong-Ju Yoo Sang-Hyun Park Kyungdo Han Dong-Wook Shin Su-Jong Yu Yoon-Jun Kim Jung-Hwan Yoon |
| author_facet | Goh-Eun Chung Young Chang Yuri Cho Eun-Ju Cho Jeong-Ju Yoo Sang-Hyun Park Kyungdo Han Dong-Wook Shin Su-Jong Yu Yoon-Jun Kim Jung-Hwan Yoon |
| author_sort | Goh-Eun Chung |
| collection | DOAJ |
| description | Background: Nonalcoholic fatty liver disease is considered to be the hepatic component of metabolic syndrome (MetS). However, the association between changes in MetS status and the risk of liver cirrhosis (LC) has not been investigated to date. This study assessed the association between changes in MetS and subsequent nonviral LC development. Methods: Data were obtained from the Korean National Health Insurance Service. Individuals who participated in health screenings from both 2009 to 2010 and 2011 to 2012 were included. The primary outcome was LC development according to the static and dynamic MetS status. Subjects were stratified into four groups according to the change in MetS status observed from the two-year interval screening (2009–2011). Cox regression analysis was used to examine the hazard ratios of LC. Results: During a median of 7.3 years of follow-up, 24,923 incident LC cases developed among 5,975,308 individuals. After adjusting for age, sex, smoking, alcohol, regular exercise, and body mass index, the adjusted hazard ratios (95% confidence intervals) for LC development were 1.39 (1.33–1.44) for the MetS-Developed group, 1.32 (1.26–1.37) for the MetS-Recovered group, and 1.51 (1.45–1.56) for the MetS-Sustained group, relative to the MetS-Free group. Stratified analyses according to age, sex, smoking, alcohol intake, exercise, diabetes mellitus, hypertension, dyslipidemia, and chronic kidney disease showed similar results. Conclusions: Both static and dynamic MetS status are independent risk factors for LC development. The risk of LC was the highest in people with sustained MetS and was lower in the MetS-Recovered group than in the MetS-Sustained group. These results suggest that improving a person’s MetS status may be helpful in preventing LC. |
| first_indexed | 2024-03-10T04:33:56Z |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:33:56Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj.art-a772d36e028c49ee9968744d9fcc690c2023-11-23T03:58:03ZengMDPI AGBiomedicines2227-90592021-12-01912194810.3390/biomedicines9121948The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver CirrhosisGoh-Eun Chung0Young Chang1Yuri Cho2Eun-Ju Cho3Jeong-Ju Yoo4Sang-Hyun Park5Kyungdo Han6Dong-Wook Shin7Su-Jong Yu8Yoon-Jun Kim9Jung-Hwan Yoon10Department of Internal Medicine, Healthcare Research Institute, Gangnam Healthcare Center, Seoul National University Hospital, Seoul 06236, KoreaDepartment of Internal Medicine, Digestive Disease Center, Institute for Digestive Research, Soonchunhyang University College of Medicine, Seoul 04401, KoreaCenter for Liver and Pancreatobiliary Cancer, Research Institute and Hospital, National Cancer Center, Goyang 10408, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Gastroenterology and Hepatology, Soonchunhyang University Bucheon Hospital, Bucheon 14584, KoreaDepartment of Biostatistics, College of Medicine, The Soongsil University, Seoul 06591, KoreaDepartment of Biostatistics, College of Medicine, The Soongsil University, Seoul 06591, KoreaSamsung Medical Center, Department of Family Medicine, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, KoreaBackground: Nonalcoholic fatty liver disease is considered to be the hepatic component of metabolic syndrome (MetS). However, the association between changes in MetS status and the risk of liver cirrhosis (LC) has not been investigated to date. This study assessed the association between changes in MetS and subsequent nonviral LC development. Methods: Data were obtained from the Korean National Health Insurance Service. Individuals who participated in health screenings from both 2009 to 2010 and 2011 to 2012 were included. The primary outcome was LC development according to the static and dynamic MetS status. Subjects were stratified into four groups according to the change in MetS status observed from the two-year interval screening (2009–2011). Cox regression analysis was used to examine the hazard ratios of LC. Results: During a median of 7.3 years of follow-up, 24,923 incident LC cases developed among 5,975,308 individuals. After adjusting for age, sex, smoking, alcohol, regular exercise, and body mass index, the adjusted hazard ratios (95% confidence intervals) for LC development were 1.39 (1.33–1.44) for the MetS-Developed group, 1.32 (1.26–1.37) for the MetS-Recovered group, and 1.51 (1.45–1.56) for the MetS-Sustained group, relative to the MetS-Free group. Stratified analyses according to age, sex, smoking, alcohol intake, exercise, diabetes mellitus, hypertension, dyslipidemia, and chronic kidney disease showed similar results. Conclusions: Both static and dynamic MetS status are independent risk factors for LC development. The risk of LC was the highest in people with sustained MetS and was lower in the MetS-Recovered group than in the MetS-Sustained group. These results suggest that improving a person’s MetS status may be helpful in preventing LC.https://www.mdpi.com/2227-9059/9/12/1948metabolic syndromecirrhosisincidencenationwide |
| spellingShingle | Goh-Eun Chung Young Chang Yuri Cho Eun-Ju Cho Jeong-Ju Yoo Sang-Hyun Park Kyungdo Han Dong-Wook Shin Su-Jong Yu Yoon-Jun Kim Jung-Hwan Yoon The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis Biomedicines metabolic syndrome cirrhosis incidence nationwide |
| title | The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis |
| title_full | The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis |
| title_fullStr | The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis |
| title_full_unstemmed | The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis |
| title_short | The Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis |
| title_sort | change in metabolic syndrome status and the risk of nonviral liver cirrhosis |
| topic | metabolic syndrome cirrhosis incidence nationwide |
| url | https://www.mdpi.com/2227-9059/9/12/1948 |
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