Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs
Purpose To evaluate the safety and efficacy of the newly designed open-cell type self-expandable nitinol stent (NiTi-stent) for peripheral arteries. Materials and Methods Twenty-eight limbs of 14 minipigs were randomly assigned to the NiTistent group or conventional nitinol stent group. Stents we...
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| Format: | Article |
| Language: | English |
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The Korean Society of Radiology
2020-07-01
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| Series: | 대한영상의학회지 |
| Subjects: | |
| Online Access: | https://doi.org/10.3348/jksr.2020.81.4.899 |
| _version_ | 1818293392650534912 |
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| author | Min Uk Kim Jae Hwan Lee Chang Jin Yoon Won Seok Choi Saebeom Hur Jin Wook Chung |
| author_facet | Min Uk Kim Jae Hwan Lee Chang Jin Yoon Won Seok Choi Saebeom Hur Jin Wook Chung |
| author_sort | Min Uk Kim |
| collection | DOAJ |
| description | Purpose To evaluate the safety and efficacy of the newly designed open-cell type self-expandable
nitinol stent (NiTi-stent) for peripheral arteries.
Materials and Methods Twenty-eight limbs of 14 minipigs were randomly assigned to the NiTistent
group or conventional nitinol stent group. Stents were symmetrically implanted into the
iliac arteries of each animal using carotid artery approach and were observed for 1 month (n =
5) and 6 months (n = 9). The angiographic lumen diameter (ALD), late lumen loss, angiographic
stenosis, histomorphometric lumen area, neointimal area, and area stenosis were analyzed and
compared between the groups.
Results Stent migration, stent fracture, or thrombus formation were not observed in either
group. At the 1-month follow-up, the neointimal area (p = 0.008) and area stenosis (p = 0.016)
were significantly smaller in the NiTi-stent group than in the control group. At the 6-months followup,
the NiTi-stent group showed significantly larger ALD (p = 0.014), less late lumen loss (p = 0.019),
less angiographic stenosis (p = 0.014), larger lumen area (p = 0.040), and smaller neointimal area
and area stenosis (p = 0.004 and p = 0.014, respectively) compared with the control group.
Conclusion The NiTi-stent is as safe and effective as the conventional nitinol stent and induces
less neointimal hyperplasia in a minipig iliac artery model. |
| first_indexed | 2024-12-13T03:15:08Z |
| format | Article |
| id | doaj.art-a7730c2bc361421b99451ddc8e05bd28 |
| institution | Directory Open Access Journal |
| issn | 1738-2637 2288-2928 |
| language | English |
| last_indexed | 2024-12-13T03:15:08Z |
| publishDate | 2020-07-01 |
| publisher | The Korean Society of Radiology |
| record_format | Article |
| series | 대한영상의학회지 |
| spelling | doaj.art-a7730c2bc361421b99451ddc8e05bd282022-12-22T00:01:30ZengThe Korean Society of Radiology대한영상의학회지1738-26372288-29282020-07-01814899911https://doi.org/10.3348/jksr.2020.81.4.899Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in MinipigsMin Uk Kim0Jae Hwan Lee1Chang Jin Yoon2Won Seok Choi3Saebeom Hur4Jin Wook Chung5Department of Radiology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, KoreaDepartment of Radiology, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Radiology, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Radiology, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, KoreaDepartment of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, KoreaPurpose To evaluate the safety and efficacy of the newly designed open-cell type self-expandable nitinol stent (NiTi-stent) for peripheral arteries. Materials and Methods Twenty-eight limbs of 14 minipigs were randomly assigned to the NiTistent group or conventional nitinol stent group. Stents were symmetrically implanted into the iliac arteries of each animal using carotid artery approach and were observed for 1 month (n = 5) and 6 months (n = 9). The angiographic lumen diameter (ALD), late lumen loss, angiographic stenosis, histomorphometric lumen area, neointimal area, and area stenosis were analyzed and compared between the groups. Results Stent migration, stent fracture, or thrombus formation were not observed in either group. At the 1-month follow-up, the neointimal area (p = 0.008) and area stenosis (p = 0.016) were significantly smaller in the NiTi-stent group than in the control group. At the 6-months followup, the NiTi-stent group showed significantly larger ALD (p = 0.014), less late lumen loss (p = 0.019), less angiographic stenosis (p = 0.014), larger lumen area (p = 0.040), and smaller neointimal area and area stenosis (p = 0.004 and p = 0.014, respectively) compared with the control group. Conclusion The NiTi-stent is as safe and effective as the conventional nitinol stent and induces less neointimal hyperplasia in a minipig iliac artery model.https://doi.org/10.3348/jksr.2020.81.4.899stentsswinenitinoliliac artery |
| spellingShingle | Min Uk Kim Jae Hwan Lee Chang Jin Yoon Won Seok Choi Saebeom Hur Jin Wook Chung Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs 대한영상의학회지 stents swine nitinol iliac artery |
| title | Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs |
| title_full | Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs |
| title_fullStr | Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs |
| title_full_unstemmed | Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs |
| title_short | Efficacy and Safety of a Newly Developed Self- Expanding Open-Cell Type Nitinol Stent for Peripheral Arteries: A Preclinical Study in Minipigs |
| title_sort | efficacy and safety of a newly developed self expanding open cell type nitinol stent for peripheral arteries a preclinical study in minipigs |
| topic | stents swine nitinol iliac artery |
| url | https://doi.org/10.3348/jksr.2020.81.4.899 |
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