Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples
Molecularly Imprinted Polymers (MIP) have demonstrated considerable potential when combined with electrochemical sensors, exhibiting high sensitivity, selectivity and reproducibility levels. The aim of this work is to detect Zivudine (ZDV) in serum samples by means of an interface imprinting techniq...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/14/10/1881 |
| _version_ | 1797572948570144768 |
|---|---|
| author | Leyla Karadurmus Sibel A. Ozkan |
| author_facet | Leyla Karadurmus Sibel A. Ozkan |
| author_sort | Leyla Karadurmus |
| collection | DOAJ |
| description | Molecularly Imprinted Polymers (MIP) have demonstrated considerable potential when combined with electrochemical sensors, exhibiting high sensitivity, selectivity and reproducibility levels. The aim of this work is to detect Zivudine (ZDV) in serum samples by means of an interface imprinting technique-based electrochemical sensor. Thus, ZDV was used as a template for the creation of an MIP-based electrochemical sensor, and differential pulse voltammetry (DPV) was used as the determination technique for the molecule. Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) techniques were also used to characterize the electrochemical sensor capabilities, which showed a good linearity between 1.0 × 10<sup>−10</sup> M and 1.0 × 10<sup>−9</sup> M. ZDV was detected with a detection limit of 1.63 × 10<sup>−11</sup> M, while the recovery analysis of spiked serum samples demonstrated that the sensor was highly selective. |
| first_indexed | 2024-03-10T21:02:50Z |
| format | Article |
| id | doaj.art-a773fbe2a42c455e8edccb2e9cdb0931 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T21:02:50Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-a773fbe2a42c455e8edccb2e9cdb09312023-11-19T17:24:13ZengMDPI AGMicromachines2072-666X2023-09-011410188110.3390/mi14101881Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological SamplesLeyla Karadurmus0Sibel A. Ozkan1Faculty of Pharmacy, Department of Analytical Chemistry, Adıyaman University, Adıyaman 02040, TürkiyeFaculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Ankara 06560, TürkiyeMolecularly Imprinted Polymers (MIP) have demonstrated considerable potential when combined with electrochemical sensors, exhibiting high sensitivity, selectivity and reproducibility levels. The aim of this work is to detect Zivudine (ZDV) in serum samples by means of an interface imprinting technique-based electrochemical sensor. Thus, ZDV was used as a template for the creation of an MIP-based electrochemical sensor, and differential pulse voltammetry (DPV) was used as the determination technique for the molecule. Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) techniques were also used to characterize the electrochemical sensor capabilities, which showed a good linearity between 1.0 × 10<sup>−10</sup> M and 1.0 × 10<sup>−9</sup> M. ZDV was detected with a detection limit of 1.63 × 10<sup>−11</sup> M, while the recovery analysis of spiked serum samples demonstrated that the sensor was highly selective.https://www.mdpi.com/2072-666X/14/10/1881molecularly imprinted polymersZidovudinevoltammetryphotopolymerization |
| spellingShingle | Leyla Karadurmus Sibel A. Ozkan Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples Micromachines molecularly imprinted polymers Zidovudine voltammetry photopolymerization |
| title | Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples |
| title_full | Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples |
| title_fullStr | Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples |
| title_full_unstemmed | Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples |
| title_short | Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples |
| title_sort | fabrication of an electrochemical sensor based on a molecularly imprinted polymer for the highly sensitive and selective determination of the antiretroviral drug zidovudine in biological samples |
| topic | molecularly imprinted polymers Zidovudine voltammetry photopolymerization |
| url | https://www.mdpi.com/2072-666X/14/10/1881 |
| work_keys_str_mv | AT leylakaradurmus fabricationofanelectrochemicalsensorbasedonamolecularlyimprintedpolymerforthehighlysensitiveandselectivedeterminationoftheantiretroviraldrugzidovudineinbiologicalsamples AT sibelaozkan fabricationofanelectrochemicalsensorbasedonamolecularlyimprintedpolymerforthehighlysensitiveandselectivedeterminationoftheantiretroviraldrugzidovudineinbiologicalsamples |