Novel Class of Potential Therapeutics that Target Ricin Retrograde Translocation

Novel Class of Potential Therapeutics that Target Ricin Retrograde Translocation

Ricin toxin, an A-B toxin from Ricinus communis, induces cell death through the inhibition of protein synthesis. The toxin binds to the cell surface via its B chain (RTB) followed by its retrograde trafficking through intracellular compartments to the ER where the A chain (RTA) is transported across...

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Bibliographic Details
Main Authors: Veronika Redmann, Thomas Gardner, Zerlina Lau, Keita Morohashi, Dan Felsenfeld, Domenico Tortorella
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Toxins
Subjects:
ricin toxin
small molecule inhibitors
high-content screen
retrograde translocation
stabilization
dislocation
egfp
ribosome-inactivating protein
Online Access:http://www.mdpi.com/2072-6651/6/1/33

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