The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/9/2185 |
| _version_ | 1827717307165573120 |
|---|---|
| author | Aneta Ostróżka-Cieślik Barbara Dolińska |
| author_facet | Aneta Ostróżka-Cieślik Barbara Dolińska |
| author_sort | Aneta Ostróżka-Cieślik |
| collection | DOAJ |
| description | Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until implantation into the recipient. Optimizations are mostly based on commercial solutions, routinely used to store grafts intended for transplantation. The paper reviews hormones with a potential nephroprotective effect, which were used to modify the composition of renal perfusion and preservation solutions. Their effectiveness as ingredients of preservation solutions was analysed based on a literature review. Hormones and trophic factors are innovative preservation solution supplements. They have a pleiotropic effect and affect normal renal function. The expression of receptors for melatonin, prolactin, thyrotropin, corticotropin, prostaglandin E1 and trophic factors was confirmed in the kidneys, which suggests that they are a promising therapeutic target for renal IR (ischemia-reperfusion) injury. They can have anti-inflammatory, antioxidant and anti-apoptotic effects, limiting IR injury. |
| first_indexed | 2024-03-10T19:59:38Z |
| format | Article |
| id | doaj.art-a7750b7fd62140a9a4424e13f566fec1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:59:38Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a7750b7fd62140a9a4424e13f566fec12023-11-19T23:41:43ZengMDPI AGMolecules1420-30492020-05-01259218510.3390/molecules25092185The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the LiteratureAneta Ostróżka-Cieślik0Barbara Dolińska1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, PolandTransplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until implantation into the recipient. Optimizations are mostly based on commercial solutions, routinely used to store grafts intended for transplantation. The paper reviews hormones with a potential nephroprotective effect, which were used to modify the composition of renal perfusion and preservation solutions. Their effectiveness as ingredients of preservation solutions was analysed based on a literature review. Hormones and trophic factors are innovative preservation solution supplements. They have a pleiotropic effect and affect normal renal function. The expression of receptors for melatonin, prolactin, thyrotropin, corticotropin, prostaglandin E1 and trophic factors was confirmed in the kidneys, which suggests that they are a promising therapeutic target for renal IR (ischemia-reperfusion) injury. They can have anti-inflammatory, antioxidant and anti-apoptotic effects, limiting IR injury.https://www.mdpi.com/1420-3049/25/9/2185renal transplantationhormonestrophic factorsorgan preservation solution |
| spellingShingle | Aneta Ostróżka-Cieślik Barbara Dolińska The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature Molecules renal transplantation hormones trophic factors organ preservation solution |
| title | The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature |
| title_full | The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature |
| title_fullStr | The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature |
| title_full_unstemmed | The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature |
| title_short | The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature |
| title_sort | role of hormones and trophic factors as components of preservation solutions in protection of renal function before transplantation a review of the literature |
| topic | renal transplantation hormones trophic factors organ preservation solution |
| url | https://www.mdpi.com/1420-3049/25/9/2185 |
| work_keys_str_mv | AT anetaostrozkacieslik theroleofhormonesandtrophicfactorsascomponentsofpreservationsolutionsinprotectionofrenalfunctionbeforetransplantationareviewoftheliterature AT barbaradolinska theroleofhormonesandtrophicfactorsascomponentsofpreservationsolutionsinprotectionofrenalfunctionbeforetransplantationareviewoftheliterature AT anetaostrozkacieslik roleofhormonesandtrophicfactorsascomponentsofpreservationsolutionsinprotectionofrenalfunctionbeforetransplantationareviewoftheliterature AT barbaradolinska roleofhormonesandtrophicfactorsascomponentsofpreservationsolutionsinprotectionofrenalfunctionbeforetransplantationareviewoftheliterature |