Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathy
Diabetic retinopathy(DR)is a neurovascular disease caused by the neurovascular unit(NVU)impairment. Immune imbalance and inflammation are key factors that affect the normal function of NVU and lead to the progression of DR. Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)infl...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-08-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/8/202308015.pdf |
| _version_ | 1797773026396209152 |
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| author | Qi Zhou Hong-Bin Lyu Ya-Ping Wang Hao-Yue Feng He-Jiang Ye |
| author_facet | Qi Zhou Hong-Bin Lyu Ya-Ping Wang Hao-Yue Feng He-Jiang Ye |
| author_sort | Qi Zhou |
| collection | DOAJ |
| description | Diabetic retinopathy(DR)is a neurovascular disease caused by the neurovascular unit(NVU)impairment. Immune imbalance and inflammation are key factors that affect the normal function of NVU and lead to the progression of DR. Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is indicated as an important component of the inflammatory response, and it can identify endogenous danger signals, leading to the activation of caspase-1 and then activating a series of inflammatory cytokines and pyroptosis. Early activation of inflammasome maintains and promotes innate immunity against bacterial and viral infections, while excessive inflammasome activation results in excessive expression and ongoing action of inflammatory proteins, which in turn triggers off immune disorders and an inflammatory cascade that seriously harms the body. This review summarizes the recent research progress on the mechanism of NLRP3 inflammasome in NVU impairment of DR, including the related drugs targeting NLRP3 pathways. |
| first_indexed | 2024-03-12T22:00:17Z |
| format | Article |
| id | doaj.art-a777cbfc93654eb194ffc7732e37a42b |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-12T22:00:17Z |
| publishDate | 2023-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-a777cbfc93654eb194ffc7732e37a42b2023-07-25T08:31:59ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-08-012381317132210.3980/j.issn.1672-5123.2023.8.15202308015Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathyQi Zhou0Hong-Bin Lyu1Ya-Ping Wang2Hao-Yue Feng3He-Jiang Ye4Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China; Department of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, ChinaDepartment of Ophthalmology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 646000, Sichuan Province, ChinaChengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, ChinaDepartment of Ophthalmology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 646000, Sichuan Province, ChinaDiabetic retinopathy(DR)is a neurovascular disease caused by the neurovascular unit(NVU)impairment. Immune imbalance and inflammation are key factors that affect the normal function of NVU and lead to the progression of DR. Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is indicated as an important component of the inflammatory response, and it can identify endogenous danger signals, leading to the activation of caspase-1 and then activating a series of inflammatory cytokines and pyroptosis. Early activation of inflammasome maintains and promotes innate immunity against bacterial and viral infections, while excessive inflammasome activation results in excessive expression and ongoing action of inflammatory proteins, which in turn triggers off immune disorders and an inflammatory cascade that seriously harms the body. This review summarizes the recent research progress on the mechanism of NLRP3 inflammasome in NVU impairment of DR, including the related drugs targeting NLRP3 pathways.http://ies.ijo.cn/cn_publish/2023/8/202308015.pdfdiabetic retinopathyneurovascular unitinflammationnucleotide-binding oligomerization domain-like receptor protein 3(nlrp3)inflammasome |
| spellingShingle | Qi Zhou Hong-Bin Lyu Ya-Ping Wang Hao-Yue Feng He-Jiang Ye Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathy Guoji Yanke Zazhi diabetic retinopathy neurovascular unit inflammation nucleotide-binding oligomerization domain-like receptor protein 3(nlrp3)inflammasome |
| title | Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathy |
| title_full | Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathy |
| title_fullStr | Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathy |
| title_full_unstemmed | Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathy |
| title_short | Research on the mechanism of NLRP3 inflammasome in neurovascular unit impairment of diabetic retinopathy |
| title_sort | research on the mechanism of nlrp3 inflammasome in neurovascular unit impairment of diabetic retinopathy |
| topic | diabetic retinopathy neurovascular unit inflammation nucleotide-binding oligomerization domain-like receptor protein 3(nlrp3)inflammasome |
| url | http://ies.ijo.cn/cn_publish/2023/8/202308015.pdf |
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