The Pathogenesis of Resection-Associated Intestinal AdaptationSummary
After massive small-bowel resection, the remnant bowel compensates by a process termed adaptation. Adaptation is characterized by villus elongation and crypt deepening, which increases the capacity for absorption and digestion per unit length. The mechanisms/mediators of this important response are...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-07-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X16300418 |
| _version_ | 1818484113182556160 |
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| author | Brad W. Warner |
| author_facet | Brad W. Warner |
| author_sort | Brad W. Warner |
| collection | DOAJ |
| description | After massive small-bowel resection, the remnant bowel compensates by a process termed adaptation. Adaptation is characterized by villus elongation and crypt deepening, which increases the capacity for absorption and digestion per unit length. The mechanisms/mediators of this important response are multiple. The purpose of this review is to highlight the major basic contributions in elucidating a more comprehensive understanding of this process. Keywords: Adaptation, Epithelium, Angiogenesis, Absorption, Villus, Apoptosis, Proliferation, Growth Factors |
| first_indexed | 2024-12-10T15:50:52Z |
| format | Article |
| id | doaj.art-a778b582efae4ababc95aabf3aed22ec |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-12-10T15:50:52Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-a778b582efae4ababc95aabf3aed22ec2022-12-22T01:42:49ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2016-07-0124429438The Pathogenesis of Resection-Associated Intestinal AdaptationSummaryBrad W. Warner0Correspondence Address correspondence to: Brad W. Warner, MD, Washington University School of Medicine, St. Louis Children's Hospital, One Children's Place, Suite 5s40, St. Louis, Missouri 63110. fax: (314) 454-2442.; Division of Pediatric Surgery, St. Louis Childrenâs Hospital, Department of Surgery, Washington University School of Medicine, St. Louis, MissouriAfter massive small-bowel resection, the remnant bowel compensates by a process termed adaptation. Adaptation is characterized by villus elongation and crypt deepening, which increases the capacity for absorption and digestion per unit length. The mechanisms/mediators of this important response are multiple. The purpose of this review is to highlight the major basic contributions in elucidating a more comprehensive understanding of this process. Keywords: Adaptation, Epithelium, Angiogenesis, Absorption, Villus, Apoptosis, Proliferation, Growth Factorshttp://www.sciencedirect.com/science/article/pii/S2352345X16300418 |
| spellingShingle | Brad W. Warner The Pathogenesis of Resection-Associated Intestinal AdaptationSummary Cellular and Molecular Gastroenterology and Hepatology |
| title | The Pathogenesis of Resection-Associated Intestinal AdaptationSummary |
| title_full | The Pathogenesis of Resection-Associated Intestinal AdaptationSummary |
| title_fullStr | The Pathogenesis of Resection-Associated Intestinal AdaptationSummary |
| title_full_unstemmed | The Pathogenesis of Resection-Associated Intestinal AdaptationSummary |
| title_short | The Pathogenesis of Resection-Associated Intestinal AdaptationSummary |
| title_sort | pathogenesis of resection associated intestinal adaptationsummary |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X16300418 |
| work_keys_str_mv | AT bradwwarner thepathogenesisofresectionassociatedintestinaladaptationsummary AT bradwwarner pathogenesisofresectionassociatedintestinaladaptationsummary |