Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride
Objective(s): Nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Temperature and pH-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in temperature and/or pH. The objective of this wor...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-07-01
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| Series: | Nanomedicine Journal |
| Subjects: | |
| Online Access: | http://nmj.mums.ac.ir/pdf_4474_73b02521e62f8db63d831976e76bef37.html |
| _version_ | 1818312672854147072 |
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| author | Sahar Mohamaddoust Aliabadi Farnaz Sadat Mirzazadeh Tekie Omid Rajabi Mohammad Reza Abbaspour Elham Khodaverdi |
| author_facet | Sahar Mohamaddoust Aliabadi Farnaz Sadat Mirzazadeh Tekie Omid Rajabi Mohammad Reza Abbaspour Elham Khodaverdi |
| author_sort | Sahar Mohamaddoust Aliabadi |
| collection | DOAJ |
| description | Objective(s): Nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Temperature and pH-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in temperature and/or pH. The objective of this work is to prepare and characterize composite membrane using responsive nanoparticles into a polymer matrix. Materials and Methods: These nanoparticles were made of the copolymer poly (N-isopropylacrylamide-co-methaçrylic acid) by an aqueous dispersion polymerization process and are responsible for dual sensitivity to temperature and pH. Morphology study with SEM, swelling behavior with Dynamic Light Scattering Technique, in vitro drug release behavior with side-by-side Diffusion Cells were also investigated in this paper. Doxorubicin hydrochloride was used as a model solute. Results:The study on the release of doxorubicin hydrochloride showed that the release rate was higher at pH 5 than pH 7.4, increased with the increase of temperature. Nevertheless, ionic strength only poses a minor direct effect at higher pH. Conclusion:Such system may be potentially used as a tumor-targeting doxorubicin hydrochloride delivery in the body. |
| first_indexed | 2024-12-13T08:21:35Z |
| format | Article |
| id | doaj.art-a778eba8138e4686b39c93ee43edec43 |
| institution | Directory Open Access Journal |
| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-12-13T08:21:35Z |
| publishDate | 2015-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-a778eba8138e4686b39c93ee43edec432022-12-21T23:54:00ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042015-07-012318719410.7508/nmj.2015.03.0034474Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochlorideSahar Mohamaddoust Aliabadi0Farnaz Sadat Mirzazadeh Tekie1Omid Rajabi2Mohammad Reza Abbaspour3Elham Khodaverdi4Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranNanotechnology Research Centre, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranTargeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranTargeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranTargeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective(s): Nowadays hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Temperature and pH-responsive delivery systems have drawn much attention because some diseases reveal themselves by a change in temperature and/or pH. The objective of this work is to prepare and characterize composite membrane using responsive nanoparticles into a polymer matrix. Materials and Methods: These nanoparticles were made of the copolymer poly (N-isopropylacrylamide-co-methaçrylic acid) by an aqueous dispersion polymerization process and are responsible for dual sensitivity to temperature and pH. Morphology study with SEM, swelling behavior with Dynamic Light Scattering Technique, in vitro drug release behavior with side-by-side Diffusion Cells were also investigated in this paper. Doxorubicin hydrochloride was used as a model solute. Results:The study on the release of doxorubicin hydrochloride showed that the release rate was higher at pH 5 than pH 7.4, increased with the increase of temperature. Nevertheless, ionic strength only poses a minor direct effect at higher pH. Conclusion:Such system may be potentially used as a tumor-targeting doxorubicin hydrochloride delivery in the body.http://nmj.mums.ac.ir/pdf_4474_73b02521e62f8db63d831976e76bef37.htmlDoxorubicin hydrochlorideNanoparticlesN-isopropylacrylamide-co-methaçrylic acidTemperature and pH-responsive delivery systems |
| spellingShingle | Sahar Mohamaddoust Aliabadi Farnaz Sadat Mirzazadeh Tekie Omid Rajabi Mohammad Reza Abbaspour Elham Khodaverdi Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride Nanomedicine Journal Doxorubicin hydrochloride Nanoparticles N-isopropylacrylamide-co-methaçrylic acid Temperature and pH-responsive delivery systems |
| title | Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride |
| title_full | Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride |
| title_fullStr | Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride |
| title_full_unstemmed | Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride |
| title_short | Polymeric composite membranes for temperature and pH-responsive delivery of doxorubicin hydrochloride |
| title_sort | polymeric composite membranes for temperature and ph responsive delivery of doxorubicin hydrochloride |
| topic | Doxorubicin hydrochloride Nanoparticles N-isopropylacrylamide-co-methaçrylic acid Temperature and pH-responsive delivery systems |
| url | http://nmj.mums.ac.ir/pdf_4474_73b02521e62f8db63d831976e76bef37.html |
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