Protective efficacy of a locally prepared bivalent duck viral hepatitis “serotypes 1 and 3” inactivated vaccine
The spread of duck hepatitis virus (DHV) in Egypt with its’ most prevalent genotypes (1 and 3) causes vast economic losses in the duck industry despite the regular vaccination with live attenuated vaccines. However, the use of live-vaccines is considered a potential risk for the non-vaccinated birds...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Ss.Cyril and Methodius University, Skopje
2024-03-01
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| Series: | Macedonian Veterinary Review |
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| Online Access: | https://macvetrev.mk/LoadArticleContent?DOI=10.2478_macvetrev_2024_0010 |
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| author | Dalia M. Omar Mohamed A. Abdrabo Nermin M. Monir Nermeen A. Marden Heba M.G. Abdelaziz Walaa A. ElSayed Nahed Yehia Sabry E. Omar Ahmed M. Erfan Abdel-Satar Arafa Momtaz A. Shahein Lamiaa M. Omar |
| author_facet | Dalia M. Omar Mohamed A. Abdrabo Nermin M. Monir Nermeen A. Marden Heba M.G. Abdelaziz Walaa A. ElSayed Nahed Yehia Sabry E. Omar Ahmed M. Erfan Abdel-Satar Arafa Momtaz A. Shahein Lamiaa M. Omar |
| author_sort | Dalia M. Omar |
| collection | DOAJ |
| description | The spread of duck hepatitis virus (DHV) in Egypt with its’ most prevalent genotypes (1 and 3) causes vast economic losses in the duck industry despite the regular vaccination with live attenuated vaccines. However, the use of live-vaccines is considered a potential risk for the non-vaccinated birds due to the viral shedding from vaccinated populations. The current study aimed to evaluate the protective efficacy and safety of two inactivated monovalent and one bivalent vaccines against DHV 1 and 3 genotypes. The inactivated monovalent (DHAV-1, DHAV-3) and bivalent (DHAV-1+3) vaccines were produced by using Montanide ISA 70 oil as an adjuvant. Three groups of 4-week-old ducklings (n=50) were vaccinated with one of the three vaccines, respectively. One group of ducklings was used as negative control (n=25). The immune-response of the vaccinated groups was measured by Virus Neutralization Test and expressed with Neutralizing Indices (NIs). The NIs for the bivalent vaccine group (5.6 and 5.4) were higher compared to the monovalent vaccine groups (5.0 and 4.7). In conclusion, the use of inactivated bivalent DHV vaccine could produce higher protective efficacy compared to the monovalent DHAV-1 and DHAV-3 vaccines. |
| first_indexed | 2024-04-24T22:55:09Z |
| format | Article |
| id | doaj.art-a77923f46f6048fe8870714cb2bc4817 |
| institution | Directory Open Access Journal |
| issn | 1409-7621 1857-7415 |
| language | English |
| last_indexed | 2024-04-24T22:55:09Z |
| publishDate | 2024-03-01 |
| publisher | Ss.Cyril and Methodius University, Skopje |
| record_format | Article |
| series | Macedonian Veterinary Review |
| spelling | doaj.art-a77923f46f6048fe8870714cb2bc48172024-03-18T08:15:26ZengSs.Cyril and Methodius University, SkopjeMacedonian Veterinary Review1409-76211857-74152024-03-0147151110.2478/macvetrev-2024-0010Protective efficacy of a locally prepared bivalent duck viral hepatitis “serotypes 1 and 3” inactivated vaccineDalia M. Omar0https://orcid.org/0000-0002-7282-4346Mohamed A. Abdrabo1https://orcid.org/0000-0003-0702-2934Nermin M. Monir2https://orcid.org/0009-0008-4283-3250Nermeen A. Marden3https://orcid.org/0009-0008-6957-0446Heba M.G. Abdelaziz4https://orcid.org/0000-0001-9763-9123Walaa A. ElSayed5https://orcid.org/0000-0002-4521-3961Nahed Yehia6https://orcid.org/0000-0002-2823-6467Sabry E. Omar7https://orcid.org/0000-0001-7086-5729Ahmed M. Erfan8https://orcid.org/0000-0001-6432-8898Abdel-Satar Arafa9https://orcid.org/0000-0001-6370-2526Momtaz A. Shahein10https://orcid.org/0000-0003-0221-8209Lamiaa M. Omar11https://orcid.org/0000-0002-8393-1788Inactivated Viral Poultry Vaccine Department (IVPVD), Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC), Cairo 11381, EgyptInactivated Viral Poultry Vaccine Department (IVPVD), Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC), Cairo 11381, EgyptInactivated Viral Poultry Vaccine Department (IVPVD), Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC), Cairo 11381, EgyptInactivated Viral Poultry Vaccine Department (IVPVD), Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC), Cairo 11381, EgyptInactivated Viral Poultry Vaccine Department (IVPVD), Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC), Cairo 11381, EgyptVeterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Cairo, 11381, EgyptNational Laboratory for Veterinary Quality Control of Poultry Production (NLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza 12618, EgyptNational Laboratory for Veterinary Quality Control of Poultry Production (NLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza 12618, EgyptNational Laboratory for Veterinary Quality Control of Poultry Production (NLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza 12618, EgyptNational Laboratory for Veterinary Quality Control of Poultry Production (NLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza 12618, EgyptNational Laboratory for Veterinary Quality Control of Poultry Production (NLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza 12618, EgyptInactivated Viral Poultry Vaccine Department (IVPVD), Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center (ARC), Cairo 11381, EgyptThe spread of duck hepatitis virus (DHV) in Egypt with its’ most prevalent genotypes (1 and 3) causes vast economic losses in the duck industry despite the regular vaccination with live attenuated vaccines. However, the use of live-vaccines is considered a potential risk for the non-vaccinated birds due to the viral shedding from vaccinated populations. The current study aimed to evaluate the protective efficacy and safety of two inactivated monovalent and one bivalent vaccines against DHV 1 and 3 genotypes. The inactivated monovalent (DHAV-1, DHAV-3) and bivalent (DHAV-1+3) vaccines were produced by using Montanide ISA 70 oil as an adjuvant. Three groups of 4-week-old ducklings (n=50) were vaccinated with one of the three vaccines, respectively. One group of ducklings was used as negative control (n=25). The immune-response of the vaccinated groups was measured by Virus Neutralization Test and expressed with Neutralizing Indices (NIs). The NIs for the bivalent vaccine group (5.6 and 5.4) were higher compared to the monovalent vaccine groups (5.0 and 4.7). In conclusion, the use of inactivated bivalent DHV vaccine could produce higher protective efficacy compared to the monovalent DHAV-1 and DHAV-3 vaccines.https://macvetrev.mk/LoadArticleContent?DOI=10.2478_macvetrev_2024_0010dhav genotype 1dhav genotype 3duck hepatitis virus type i (dhav)inactivated duck hepatitis vaccineneutralization index (ni) |
| spellingShingle | Dalia M. Omar Mohamed A. Abdrabo Nermin M. Monir Nermeen A. Marden Heba M.G. Abdelaziz Walaa A. ElSayed Nahed Yehia Sabry E. Omar Ahmed M. Erfan Abdel-Satar Arafa Momtaz A. Shahein Lamiaa M. Omar Protective efficacy of a locally prepared bivalent duck viral hepatitis “serotypes 1 and 3” inactivated vaccine Macedonian Veterinary Review dhav genotype 1 dhav genotype 3 duck hepatitis virus type i (dhav) inactivated duck hepatitis vaccine neutralization index (ni) |
| title | Protective efficacy of a locally prepared bivalent duck viral hepatitis “serotypes 1 and 3” inactivated vaccine |
| title_full | Protective efficacy of a locally prepared bivalent duck viral hepatitis “serotypes 1 and 3” inactivated vaccine |
| title_fullStr | Protective efficacy of a locally prepared bivalent duck viral hepatitis “serotypes 1 and 3” inactivated vaccine |
| title_full_unstemmed | Protective efficacy of a locally prepared bivalent duck viral hepatitis “serotypes 1 and 3” inactivated vaccine |
| title_short | Protective efficacy of a locally prepared bivalent duck viral hepatitis “serotypes 1 and 3” inactivated vaccine |
| title_sort | protective efficacy of a locally prepared bivalent duck viral hepatitis serotypes 1 and 3 inactivated vaccine |
| topic | dhav genotype 1 dhav genotype 3 duck hepatitis virus type i (dhav) inactivated duck hepatitis vaccine neutralization index (ni) |
| url | https://macvetrev.mk/LoadArticleContent?DOI=10.2478_macvetrev_2024_0010 |
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