EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINT
The wide surgery on hip joint is followed by the blood loss, local and systematic inflammatory response. Tranexamic acid is widely used in surgery for conservative homeostasis and its anti-inflammatory effect is also well known. The purpose: to justify the dosing regimen of tranexamic acid from the ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2017-12-01
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| Series: | Вестник анестезиологии и реаниматологии |
| Subjects: | |
| Online Access: | https://www.vair-journal.com/jour/article/view/76 |
| _version_ | 1826567042195521536 |
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| author | T. A. Zhirova E. B. Makarova V. A. Rudnov |
| author_facet | T. A. Zhirova E. B. Makarova V. A. Rudnov |
| author_sort | T. A. Zhirova |
| collection | DOAJ |
| description | The wide surgery on hip joint is followed by the blood loss, local and systematic inflammatory response. Tranexamic acid is widely used in surgery for conservative homeostasis and its anti-inflammatory effect is also well known. The purpose: to justify the dosing regimen of tranexamic acid from the position of minimum blood loss and inflammatory response. Materials and methods: 32 patients from the control group received standard therapy with tranexamic acid at the dose of 20 mg/kg intravenously twice a day: 30 minutes prior to the surgery and in 6 hours since the 1st administration; in the main group (29 patients) the standard regimen was supplemented by intra-operative administration – 10 mg per kg-1 ∙ h-1. Results. The volume of the intra-surgery, drainage, general and estimated peri-operative blood loss was not statistically different between two groups. The level of pro-inflammatory and anti-inflammatory cytokines was higher in the drainage blood compared to the peripheral one (p < 0.001). The concentration of soluble receptors to IL-6 and FNO-α was statistically and clinically confidently higher in the control group compared to the main one at the majority stages of the study (p < 0.05). Conclusion. Tranexamic acid possesses anti-inflammatory action regardless of the dose. |
| first_indexed | 2024-03-12T03:06:21Z |
| format | Article |
| id | doaj.art-a779b9386d28416394500721ec19db0c |
| institution | Directory Open Access Journal |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| last_indexed | 2025-03-14T11:01:15Z |
| publishDate | 2017-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj.art-a779b9386d28416394500721ec19db0c2025-03-02T10:44:27ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532017-12-01131303710.21292/2078-5658-2016-13-1-30-3776EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINTT. A. Zhirova0E. B. Makarova1V. A. Rudnov2V. D. Chaklin Ural Research Institute of Traumotology and orthopedics, YekaterinburgV. D. Chaklin Ural Research Institute of Traumotology and orthopedics, YekaterinburgUral State Medical University, YekaterinburgThe wide surgery on hip joint is followed by the blood loss, local and systematic inflammatory response. Tranexamic acid is widely used in surgery for conservative homeostasis and its anti-inflammatory effect is also well known. The purpose: to justify the dosing regimen of tranexamic acid from the position of minimum blood loss and inflammatory response. Materials and methods: 32 patients from the control group received standard therapy with tranexamic acid at the dose of 20 mg/kg intravenously twice a day: 30 minutes prior to the surgery and in 6 hours since the 1st administration; in the main group (29 patients) the standard regimen was supplemented by intra-operative administration – 10 mg per kg-1 ∙ h-1. Results. The volume of the intra-surgery, drainage, general and estimated peri-operative blood loss was not statistically different between two groups. The level of pro-inflammatory and anti-inflammatory cytokines was higher in the drainage blood compared to the peripheral one (p < 0.001). The concentration of soluble receptors to IL-6 and FNO-α was statistically and clinically confidently higher in the control group compared to the main one at the majority stages of the study (p < 0.05). Conclusion. Tranexamic acid possesses anti-inflammatory action regardless of the dose.https://www.vair-journal.com/jour/article/view/76tranexamic acid, endoprosthesis of the hip jointlocal inflammatory reactionsystem inflammatory reactioncytokinesloss of blood |
| spellingShingle | T. A. Zhirova E. B. Makarova V. A. Rudnov EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINT Вестник анестезиологии и реаниматологии tranexamic acid, endoprosthesis of the hip joint local inflammatory reaction system inflammatory reaction cytokines loss of blood |
| title | EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINT |
| title_full | EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINT |
| title_fullStr | EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINT |
| title_full_unstemmed | EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINT |
| title_short | EFFECTS OF TRANEXAMIC ACID IN THE WIDE RECONSTRUCTIVE SURGERY ON HIP JOINT |
| title_sort | effects of tranexamic acid in the wide reconstructive surgery on hip joint |
| topic | tranexamic acid, endoprosthesis of the hip joint local inflammatory reaction system inflammatory reaction cytokines loss of blood |
| url | https://www.vair-journal.com/jour/article/view/76 |
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