Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties
Nanoparticles of metals can be toxic to bacteria, showing biocidal activities at low concentrations. Metal, oxide, or compounds based on copper are applied like antimicrobial agents. The capacity of integration of metallic nanoparticles in polymer matrices has improved the antimicrobial behavior, re...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-08-01
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| Series: | Dose-Response |
| Online Access: | https://doi.org/10.1177/1559325819869502 |
| _version_ | 1818317087752323072 |
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| author | Antonio Muñoz-Escobar Álvaro de Jesús Ruíz-Baltazar Simón Yobanny Reyes-López |
| author_facet | Antonio Muñoz-Escobar Álvaro de Jesús Ruíz-Baltazar Simón Yobanny Reyes-López |
| author_sort | Antonio Muñoz-Escobar |
| collection | DOAJ |
| description | Nanoparticles of metals can be toxic to bacteria, showing biocidal activities at low concentrations. Metal, oxide, or compounds based on copper are applied like antimicrobial agents. The capacity of integration of metallic nanoparticles in polymer matrices has improved the antimicrobial behavior, resulting in the search for composites with increased bactericidal properties. A polycaprolactone (PCL) film polymer with copper oxide nanoparticles (CuONPs) was prepared. Dynamic light scattering analysis showed the sizes from 88 to 97 nm of CuONPs. Scanning electron microscopy (SEM) revealed CuONPs with semispherical shapes with diameter 35 nm. The prepared PCL-CuONPs exhibited a nanoporous structure by SEM. The antibacterial applicability of the composite was evaluated to determine the minimum inhibitory concentration in 6 different bacteria and the experimental tests were carried by disk diffusion and spectrophotometric methods. The PCL-CuONPs exhibit a considerable antibacterial effect in gram-positive bacteria in contrast to gram-negative bacteria. The preparation of PCL-CuONPs was simple, fast, and low cost for practical application as wound dressings. |
| first_indexed | 2024-12-13T09:31:45Z |
| format | Article |
| id | doaj.art-a77b979b30944ce7866ed1518dda87a5 |
| institution | Directory Open Access Journal |
| issn | 1559-3258 |
| language | English |
| last_indexed | 2024-12-13T09:31:45Z |
| publishDate | 2019-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Dose-Response |
| spelling | doaj.art-a77b979b30944ce7866ed1518dda87a52022-12-21T23:52:28ZengSAGE PublishingDose-Response1559-32582019-08-011710.1177/1559325819869502Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial PropertiesAntonio Muñoz-Escobar0Álvaro de Jesús Ruíz-Baltazar1Simón Yobanny Reyes-López2 Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez, Chihuahua, Mexico Conacyt-Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Juriquilla Querétaro, Mexico Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez, Chihuahua, MexicoNanoparticles of metals can be toxic to bacteria, showing biocidal activities at low concentrations. Metal, oxide, or compounds based on copper are applied like antimicrobial agents. The capacity of integration of metallic nanoparticles in polymer matrices has improved the antimicrobial behavior, resulting in the search for composites with increased bactericidal properties. A polycaprolactone (PCL) film polymer with copper oxide nanoparticles (CuONPs) was prepared. Dynamic light scattering analysis showed the sizes from 88 to 97 nm of CuONPs. Scanning electron microscopy (SEM) revealed CuONPs with semispherical shapes with diameter 35 nm. The prepared PCL-CuONPs exhibited a nanoporous structure by SEM. The antibacterial applicability of the composite was evaluated to determine the minimum inhibitory concentration in 6 different bacteria and the experimental tests were carried by disk diffusion and spectrophotometric methods. The PCL-CuONPs exhibit a considerable antibacterial effect in gram-positive bacteria in contrast to gram-negative bacteria. The preparation of PCL-CuONPs was simple, fast, and low cost for practical application as wound dressings.https://doi.org/10.1177/1559325819869502 |
| spellingShingle | Antonio Muñoz-Escobar Álvaro de Jesús Ruíz-Baltazar Simón Yobanny Reyes-López Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties Dose-Response |
| title | Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties |
| title_full | Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties |
| title_fullStr | Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties |
| title_full_unstemmed | Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties |
| title_short | Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties |
| title_sort | novel route of synthesis of pcl cuonps composites with antimicrobial properties |
| url | https://doi.org/10.1177/1559325819869502 |
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