Low-grade gliomas: A single-institute experience
Introduction: Low-grade gliomas (LGG) are relatively rare tumors. They comprise 5% of all brain tumors and 15% of all gliomas. As per WHO classification diffuse infiltrating LGG s fall under Grade II tumors. Although these tumors are slow growing but eventually they progress to high-grade gliomas, s...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Radiation and Cancer Research |
| Subjects: | |
| Online Access: | http://www.journalrcr.org/article.asp?issn=2588-9273;year=2022;volume=13;issue=1;spage=23;epage=27;aulast=Nasreen |
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| author | Shahida Nasreen Arshad Manzoor Najmi Asifa Andleeb Kaneez Fatima Mushtaq A Sofi Saquib Zaffar Banday |
| author_facet | Shahida Nasreen Arshad Manzoor Najmi Asifa Andleeb Kaneez Fatima Mushtaq A Sofi Saquib Zaffar Banday |
| author_sort | Shahida Nasreen |
| collection | DOAJ |
| description | Introduction: Low-grade gliomas (LGG) are relatively rare tumors. They comprise 5% of all brain tumors and 15% of all gliomas. As per WHO classification diffuse infiltrating LGG s fall under Grade II tumors. Although these tumors are slow growing but eventually they progress to high-grade gliomas, so these patients should be treated aggressively. Materials and Methods: From January 2012 to January 2017, clinical information of patients, who had LGG, was collected retrospectively from patient registries at the radiation oncology department of our institute. Results: A total of 25 patients were analyzed. Out of the entire cohort, 64% were males, and 36% were females. The most common presenting symptom in our patients was seizures and blurring of vision (44% each). Cerebrum was the mos common site of lesion in 19 out of 25 (76.0%) cases, and among those 19 cases, frontal lobe was involved in 12 cases (63.1%). Craniotomy with tumor decompression was performed in all patients. Gross total excision was possible in only 2 (8%) out of 25 patients, whereas the remaining 23 (92%) patients underwent subtotal or near total excision only. These 23 patients received concurrent chemoradiation by cobalt-60 unit to a dose of 60 Gy with weekly temozolomide. 18 out of 23 (78.2%) patients received adjuvant six cycles temozolomidein view of residual disease after concurrent chemoradiotherapy. At the last follow-up, all the 25 patients were alive, 20 patients had no disease on contrast-enhanced magnetic resonance imaging, while five patients had stable disease. Conclusion: We conclude that LGG is a disease of young adults with seizures as most common presenting symptom. If treated with multidisciplinary treatment these patients have the long disease and disability-free survival. Neurocognitive dysfunction is low in our study group, but it needs longer follow-up. |
| first_indexed | 2024-04-14T02:41:34Z |
| format | Article |
| id | doaj.art-a77c39957edc46cbb9f822f7992d3b03 |
| institution | Directory Open Access Journal |
| issn | 2588-9273 2468-9203 |
| language | English |
| last_indexed | 2024-04-14T02:41:34Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Radiation and Cancer Research |
| spelling | doaj.art-a77c39957edc46cbb9f822f7992d3b032022-12-22T02:17:03ZengWolters Kluwer Medknow PublicationsJournal of Radiation and Cancer Research2588-92732468-92032022-01-01131232710.4103/jrcr.jrcr_42_21Low-grade gliomas: A single-institute experienceShahida NasreenArshad Manzoor NajmiAsifa AndleebKaneez FatimaMushtaq A SofiSaquib Zaffar BandayIntroduction: Low-grade gliomas (LGG) are relatively rare tumors. They comprise 5% of all brain tumors and 15% of all gliomas. As per WHO classification diffuse infiltrating LGG s fall under Grade II tumors. Although these tumors are slow growing but eventually they progress to high-grade gliomas, so these patients should be treated aggressively. Materials and Methods: From January 2012 to January 2017, clinical information of patients, who had LGG, was collected retrospectively from patient registries at the radiation oncology department of our institute. Results: A total of 25 patients were analyzed. Out of the entire cohort, 64% were males, and 36% were females. The most common presenting symptom in our patients was seizures and blurring of vision (44% each). Cerebrum was the mos common site of lesion in 19 out of 25 (76.0%) cases, and among those 19 cases, frontal lobe was involved in 12 cases (63.1%). Craniotomy with tumor decompression was performed in all patients. Gross total excision was possible in only 2 (8%) out of 25 patients, whereas the remaining 23 (92%) patients underwent subtotal or near total excision only. These 23 patients received concurrent chemoradiation by cobalt-60 unit to a dose of 60 Gy with weekly temozolomide. 18 out of 23 (78.2%) patients received adjuvant six cycles temozolomidein view of residual disease after concurrent chemoradiotherapy. At the last follow-up, all the 25 patients were alive, 20 patients had no disease on contrast-enhanced magnetic resonance imaging, while five patients had stable disease. Conclusion: We conclude that LGG is a disease of young adults with seizures as most common presenting symptom. If treated with multidisciplinary treatment these patients have the long disease and disability-free survival. Neurocognitive dysfunction is low in our study group, but it needs longer follow-up.http://www.journalrcr.org/article.asp?issn=2588-9273;year=2022;volume=13;issue=1;spage=23;epage=27;aulast=Nasreenchemotherapylow-grade gliomaradiotherapysurvival |
| spellingShingle | Shahida Nasreen Arshad Manzoor Najmi Asifa Andleeb Kaneez Fatima Mushtaq A Sofi Saquib Zaffar Banday Low-grade gliomas: A single-institute experience Journal of Radiation and Cancer Research chemotherapy low-grade glioma radiotherapy survival |
| title | Low-grade gliomas: A single-institute experience |
| title_full | Low-grade gliomas: A single-institute experience |
| title_fullStr | Low-grade gliomas: A single-institute experience |
| title_full_unstemmed | Low-grade gliomas: A single-institute experience |
| title_short | Low-grade gliomas: A single-institute experience |
| title_sort | low grade gliomas a single institute experience |
| topic | chemotherapy low-grade glioma radiotherapy survival |
| url | http://www.journalrcr.org/article.asp?issn=2588-9273;year=2022;volume=13;issue=1;spage=23;epage=27;aulast=Nasreen |
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