Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents

Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents

Three novel pyrazolo-[4,3-<i>e</i>][1,2,4]triazolopyrimidine derivatives (<b>1</b>, <b>2</b>, and <b>3</b>) were designed, synthesized, and evaluated for their in vitro biological activity. All three compounds exhibited different levels of cytotoxicity...

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Bibliographic Details
Main Authors:	Saeb Aliwaini, Bassam Abu Thaher, Ihab Al-Masri, Nabil Shurrab, Said El-Kurdi, Dieter Schollmeyer, Basem Qeshta, Mariam Ghunaim, René Csuk, Stefan Laufer, Lars Kaiser, Hans-Peter Deigner
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Molecules
Subjects:	pyrazolo[1,2,4]triazolopyrimidine EGF-receptor inhibitor breast cancer cervical cancer molecular docking crystal X-ray analysis
Online Access:	https://www.mdpi.com/1420-3049/26/13/4065

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