Nicolau syndrome associated with fluphenazine depot: A case report
Nicolau syndrome is a rare condition characterized by severe pain at the site of injection, leading to ulceration and necrosis of the local tissues. Its presentation is usually acute. Nicolau syndrome is commonly seen in patients after intramuscular, intra-articular, or subcutaneous injections of no...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-06-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X231180747 |
| _version_ | 1797790499940073472 |
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| author | Soumitra Das Vallabh Shet Thusanth Jogarajah Abdulgafar Ibrahim Marlon Reyes Elaiza Marie Fernandez Co Balaswamy Reddy |
| author_facet | Soumitra Das Vallabh Shet Thusanth Jogarajah Abdulgafar Ibrahim Marlon Reyes Elaiza Marie Fernandez Co Balaswamy Reddy |
| author_sort | Soumitra Das |
| collection | DOAJ |
| description | Nicolau syndrome is a rare condition characterized by severe pain at the site of injection, leading to ulceration and necrosis of the local tissues. Its presentation is usually acute. Nicolau syndrome is commonly seen in patients after intramuscular, intra-articular, or subcutaneous injections of non-steroidal anti-inflammatory drugs, antiepileptics, antipsychotics, antibiotics, antihistamines, and corticosteroids. Immediate diagnosis and management of this syndrome are of great importance. We herein report a rare presentation of Nicolau syndrome in a 36-year-old married male who suffered from paranoid schizophrenia for the past 3 years. The patient presented with dull pain, mild swelling, and necrotic ulceration over the injection site after receiving intramuscular fluphenazine. The patient underwent wound debridement and was given prophylactic antibiotics. Despite a wide range of therapeutic options for the management of Nicolau syndrome described in the literature, there exist limited guidelines for its management. |
| first_indexed | 2024-03-13T02:05:29Z |
| format | Article |
| id | doaj.art-a77d77fd4bfe439cb13acce4ed1cc660 |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-03-13T02:05:29Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-a77d77fd4bfe439cb13acce4ed1cc6602023-07-01T09:03:21ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2023-06-011110.1177/2050313X231180747Nicolau syndrome associated with fluphenazine depot: A case reportSoumitra Das0Vallabh Shet1Thusanth Jogarajah2Abdulgafar Ibrahim3Marlon Reyes4Elaiza Marie Fernandez Co5Balaswamy Reddy6The Royal Melbourne Hospital, Parkville, VIC, AustraliaBangalore Medical College & Research Institute, Bangalore, IndiaFaculty of Medicine, Richmond Gabriel University, Belair, Saint Vincent and the GrenadinesInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USAAmerican University of Antigua College of Medicine, St. John’s, Antigua and BarbudaCebu Institute of Medicine, Cebu City, PhilippinesDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, IndiaNicolau syndrome is a rare condition characterized by severe pain at the site of injection, leading to ulceration and necrosis of the local tissues. Its presentation is usually acute. Nicolau syndrome is commonly seen in patients after intramuscular, intra-articular, or subcutaneous injections of non-steroidal anti-inflammatory drugs, antiepileptics, antipsychotics, antibiotics, antihistamines, and corticosteroids. Immediate diagnosis and management of this syndrome are of great importance. We herein report a rare presentation of Nicolau syndrome in a 36-year-old married male who suffered from paranoid schizophrenia for the past 3 years. The patient presented with dull pain, mild swelling, and necrotic ulceration over the injection site after receiving intramuscular fluphenazine. The patient underwent wound debridement and was given prophylactic antibiotics. Despite a wide range of therapeutic options for the management of Nicolau syndrome described in the literature, there exist limited guidelines for its management.https://doi.org/10.1177/2050313X231180747 |
| spellingShingle | Soumitra Das Vallabh Shet Thusanth Jogarajah Abdulgafar Ibrahim Marlon Reyes Elaiza Marie Fernandez Co Balaswamy Reddy Nicolau syndrome associated with fluphenazine depot: A case report SAGE Open Medical Case Reports |
| title | Nicolau syndrome associated with fluphenazine depot: A case report |
| title_full | Nicolau syndrome associated with fluphenazine depot: A case report |
| title_fullStr | Nicolau syndrome associated with fluphenazine depot: A case report |
| title_full_unstemmed | Nicolau syndrome associated with fluphenazine depot: A case report |
| title_short | Nicolau syndrome associated with fluphenazine depot: A case report |
| title_sort | nicolau syndrome associated with fluphenazine depot a case report |
| url | https://doi.org/10.1177/2050313X231180747 |
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