T Cell Dysfunction in Cancer Immunity and Immunotherapy

T Cell Dysfunction in Cancer Immunity and Immunotherapy

In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional T cells are characterized by reduced proliferative capacity, decreased effector function, and overexpression of multiple inhibitory receptors. Due to the presence of various inhibitory signals in the complex...

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Bibliographic Details
Main Authors: Anliang Xia, Yan Zhang, Jiang Xu, Tailang Yin, Xiao-Jie Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
T cell dysfunction
immunity
cancer
immunotherapy
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01719/full

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