Liver morbidity among haemodialysis patients negative for manifest HBV and HCV : A hospital-based study in an endemic area
Background: End-stage renal disease (ESRD) is an increasing health problem worldwide. Older age, diabetes mellitus and hypertension, acute kidney damage are among some of the factors that play a role in ESRD. This study aims at exploring liver morbidity (LM) among Egyptian hemodialysis (HD) patient...
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| Format: | Article |
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Zagazig University, Faculty of Medicine
2022-08-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_235028_5b565e9edada828168f8dcb475bc24de.pdf |
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| author | Abdulrahman Alduraywish Moustafa Ragheb Rania Kishk Ibrahim Taher Hamdy Hassan Hassan Mahmoud Omar Nageh Louis Mahrous wafaa omar |
| author_facet | Abdulrahman Alduraywish Moustafa Ragheb Rania Kishk Ibrahim Taher Hamdy Hassan Hassan Mahmoud Omar Nageh Louis Mahrous wafaa omar |
| author_sort | Abdulrahman Alduraywish |
| collection | DOAJ |
| description | Background: End-stage renal disease (ESRD) is an increasing health problem worldwide. Older age, diabetes mellitus and hypertension, acute kidney damage are among some of the factors that play a role in ESRD. This study aims at exploring liver morbidity (LM) among Egyptian hemodialysis (HD) patients. Methods: The study included 142 patients free from overt hepatitis B virus (HBV) or hepatitis C virus (HCV); their data were retrieved from files and all were clinically assessed and tested for liver functions, serological markers and viremia of HCV and HBV. Results: Of 142 eligible HD patients, two seroconverted to overt HCV, and five showed occult HCV. According to the laboratory and ultrasonography (US) data, three patterns of LM were found in 62 (43.7%), non-alcoholic fatty liver disease (NAFLD) in 30 (48.4%), liver fibrosis in 19 (30.6%), and hepatitis in 13 (21%). The mean durations of renal impairment (7.6 ± 5.91), hemodialysis (9 ± 6.1269), and total dialysis sessions (976.26 ± 683.69) were significantly higher in patients with LM compared to others (6.78 ± 4.82, 5.38 ± 3.69, and 699.4 ± 467.1). Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) levels were elevated in 14 (22.6%) and 13 (21%) of patients with LM. However, the ROC curve revealed ALT and AST cut-off points of 16.5 and 25.5 IU/L to discriminate LM. Conclusion: LM is common among EDRD patients undergoing hemodialysis despite the low levels of ALT and AST. The use of the US and the new lower levels of ALT and AST could improve the screening approach of LM. |
| first_indexed | 2024-04-11T09:15:13Z |
| format | Article |
| id | doaj.art-a7847cf5feb6478985bc19b925749554 |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-04-11T09:15:13Z |
| publishDate | 2022-08-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-a7847cf5feb6478985bc19b9257495542022-12-22T04:32:24ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402022-08-013357858710.21608/mid.2022.132560.1274235028Liver morbidity among haemodialysis patients negative for manifest HBV and HCV : A hospital-based study in an endemic areaAbdulrahman Alduraywish0Moustafa Ragheb1Rania Kishk2Ibrahim Taher3Hamdy Hassan Hassan Mahmoud Omar4Nageh Louis Mahrous5wafaa omar6Jouf UniversityDepartment of infectious diseasesMicrobiology And Immunology Department, Faculty Of Medicine, Suez Canal University Round Road 4.5kmJouf UniversitySuez Canal Universitydepartment of endemic and infectious diseasesFaculty of medicine , Suez Canal UniversityBackground: End-stage renal disease (ESRD) is an increasing health problem worldwide. Older age, diabetes mellitus and hypertension, acute kidney damage are among some of the factors that play a role in ESRD. This study aims at exploring liver morbidity (LM) among Egyptian hemodialysis (HD) patients. Methods: The study included 142 patients free from overt hepatitis B virus (HBV) or hepatitis C virus (HCV); their data were retrieved from files and all were clinically assessed and tested for liver functions, serological markers and viremia of HCV and HBV. Results: Of 142 eligible HD patients, two seroconverted to overt HCV, and five showed occult HCV. According to the laboratory and ultrasonography (US) data, three patterns of LM were found in 62 (43.7%), non-alcoholic fatty liver disease (NAFLD) in 30 (48.4%), liver fibrosis in 19 (30.6%), and hepatitis in 13 (21%). The mean durations of renal impairment (7.6 ± 5.91), hemodialysis (9 ± 6.1269), and total dialysis sessions (976.26 ± 683.69) were significantly higher in patients with LM compared to others (6.78 ± 4.82, 5.38 ± 3.69, and 699.4 ± 467.1). Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) levels were elevated in 14 (22.6%) and 13 (21%) of patients with LM. However, the ROC curve revealed ALT and AST cut-off points of 16.5 and 25.5 IU/L to discriminate LM. Conclusion: LM is common among EDRD patients undergoing hemodialysis despite the low levels of ALT and AST. The use of the US and the new lower levels of ALT and AST could improve the screening approach of LM.https://mid.journals.ekb.eg/article_235028_5b565e9edada828168f8dcb475bc24de.pdfend-stage kidney diseasechronic liver diseaseultrasonographyalanine aminotransferaseaspartate aminotransferase |
| spellingShingle | Abdulrahman Alduraywish Moustafa Ragheb Rania Kishk Ibrahim Taher Hamdy Hassan Hassan Mahmoud Omar Nageh Louis Mahrous wafaa omar Liver morbidity among haemodialysis patients negative for manifest HBV and HCV : A hospital-based study in an endemic area Microbes and Infectious Diseases end-stage kidney disease chronic liver disease ultrasonography alanine aminotransferase aspartate aminotransferase |
| title | Liver morbidity among haemodialysis patients negative for manifest HBV and HCV : A hospital-based study in an endemic area |
| title_full | Liver morbidity among haemodialysis patients negative for manifest HBV and HCV : A hospital-based study in an endemic area |
| title_fullStr | Liver morbidity among haemodialysis patients negative for manifest HBV and HCV : A hospital-based study in an endemic area |
| title_full_unstemmed | Liver morbidity among haemodialysis patients negative for manifest HBV and HCV : A hospital-based study in an endemic area |
| title_short | Liver morbidity among haemodialysis patients negative for manifest HBV and HCV : A hospital-based study in an endemic area |
| title_sort | liver morbidity among haemodialysis patients negative for manifest hbv and hcv a hospital based study in an endemic area |
| topic | end-stage kidney disease chronic liver disease ultrasonography alanine aminotransferase aspartate aminotransferase |
| url | https://mid.journals.ekb.eg/article_235028_5b565e9edada828168f8dcb475bc24de.pdf |
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