Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition.
Despite the increasingly recognized importance of the tumor microenvironment (TME) as a regulator of tumor progression, only few in vitro models have been developed to systematically study the effects of TME on tumor behavior in a controlled manner. Here we developed a three-dimensional (3D) in vitr...
Main Authors: | R Marisol Herrera-Perez, Sherry L Voytik-Harbin, Jann N Sarkaria, Karen E Pollok, Melissa L Fishel, Jenna L Rickus |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5863989?pdf=render |
Similar Items
-
Perivascular Stromal Cells Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model
by: Mai T. Ngo, et al.
Published: (2022-11-01) -
20184 A Hypothesis-Driven Parametric Study of a Computational Dermal Replacement Model
by: David Sohutskay, et al.
Published: (2021-03-01) -
Pivotal Role of STAT3 in Shaping Glioblastoma Immune Microenvironment
by: Christina Piperi, et al.
Published: (2019-11-01) -
Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior
by: Jee-Wei E. Chen, et al.
Published: (2018-06-01) -
3D collagen fibrillar microstructure guides pancreatic cancer cell phenotype and serves as a critical design parameter for phenotypic models of EMT.
by: T J Puls, et al.
Published: (2017-01-01)