Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-<i>life</i> Study
The role of miR-24-1-5p and its prognostic implications associated with prostate cancer are mainly unknown. In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-<i>life</i>), all men had a general health examination at study entry and were followed between 1994...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/5/1142 |
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| author | Einar Stikbakke Tom Wilsgaard Hege Sagstuen Haugnes Mona Irene Pedersen Tore Knutsen Martin Støyten Edward Giovannucci Anne Elise Eggen Inger Thune Elin Richardsen |
| author_facet | Einar Stikbakke Tom Wilsgaard Hege Sagstuen Haugnes Mona Irene Pedersen Tore Knutsen Martin Støyten Edward Giovannucci Anne Elise Eggen Inger Thune Elin Richardsen |
| author_sort | Einar Stikbakke |
| collection | DOAJ |
| description | The role of miR-24-1-5p and its prognostic implications associated with prostate cancer are mainly unknown. In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-<i>life</i>), all men had a general health examination at study entry and were followed between 1994 and 2016. Patients with available tissue samples after a prostatectomy with curative intent were identified (<i>n</i> = 189). The tissue expression of miR-24-1-5p in prostate cancer was examined by in situ hybridization (ISH) in tissue microarray (TMA) blocks by semi-quantitative scoring by two independent investigators. Multivariable Cox regression models were used to study the associations between miR-24-1-5p expression and prostate cancer recurrence. The prostate cancer patients had a median age of 65.0 years (range 47–75 years). The Cancer of the Prostate Risk Assessment Postsurgical Score, International Society of Urological Pathology grade group, and European Association of Urology Risk group were all significant prognostic factors for five-year recurrence-free survival (<i>p</i> < 0.001). Prostate cancer patients with a high miR-24-1-5p expression (≥1.57) in the tissue had a doubled risk of recurrence compared to patients with low expression (HR 1.99, 95% CI 1.13–3.51). Our study suggests that a high expression of miR-24-1-5p is associated with an increased risk of recurrence of prostate cancer after radical prostatectomy, which points to the potential diagnostic and therapeutic value of detecting miR-24-1-5p in prostate cancer cases. |
| first_indexed | 2024-03-09T20:45:55Z |
| format | Article |
| id | doaj.art-a787fc7214504a02a76400d74a70d08a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:45:55Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a787fc7214504a02a76400d74a70d08a2023-11-23T22:46:30ZengMDPI AGCancers2072-66942022-02-01145114210.3390/cancers14051142Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-<i>life</i> StudyEinar Stikbakke0Tom Wilsgaard1Hege Sagstuen Haugnes2Mona Irene Pedersen3Tore Knutsen4Martin Støyten5Edward Giovannucci6Anne Elise Eggen7Inger Thune8Elin Richardsen9Department of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayDepartment of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayDepartment of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayTranslational Cancer Research Group, Institute of Clinical Medicine, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayDepartment of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayDepartment of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayDepartment of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayTranslational Cancer Research Group, Institute of Clinical Medicine, UiT, The Arctic University of Norway, 9037 Tromsø, NorwayThe role of miR-24-1-5p and its prognostic implications associated with prostate cancer are mainly unknown. In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-<i>life</i>), all men had a general health examination at study entry and were followed between 1994 and 2016. Patients with available tissue samples after a prostatectomy with curative intent were identified (<i>n</i> = 189). The tissue expression of miR-24-1-5p in prostate cancer was examined by in situ hybridization (ISH) in tissue microarray (TMA) blocks by semi-quantitative scoring by two independent investigators. Multivariable Cox regression models were used to study the associations between miR-24-1-5p expression and prostate cancer recurrence. The prostate cancer patients had a median age of 65.0 years (range 47–75 years). The Cancer of the Prostate Risk Assessment Postsurgical Score, International Society of Urological Pathology grade group, and European Association of Urology Risk group were all significant prognostic factors for five-year recurrence-free survival (<i>p</i> < 0.001). Prostate cancer patients with a high miR-24-1-5p expression (≥1.57) in the tissue had a doubled risk of recurrence compared to patients with low expression (HR 1.99, 95% CI 1.13–3.51). Our study suggests that a high expression of miR-24-1-5p is associated with an increased risk of recurrence of prostate cancer after radical prostatectomy, which points to the potential diagnostic and therapeutic value of detecting miR-24-1-5p in prostate cancer cases.https://www.mdpi.com/2072-6694/14/5/1142prostate cancermicroRNAmiR-24-1-5pradical prostatectomybiomarkerpopulation study |
| spellingShingle | Einar Stikbakke Tom Wilsgaard Hege Sagstuen Haugnes Mona Irene Pedersen Tore Knutsen Martin Støyten Edward Giovannucci Anne Elise Eggen Inger Thune Elin Richardsen Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-<i>life</i> Study Cancers prostate cancer microRNA miR-24-1-5p radical prostatectomy biomarker population study |
| title | Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-<i>life</i> Study |
| title_full | Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-<i>life</i> Study |
| title_fullStr | Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-<i>life</i> Study |
| title_full_unstemmed | Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-<i>life</i> Study |
| title_short | Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-<i>life</i> Study |
| title_sort | expression of mir 24 1 5p in tumor tissue influences prostate cancer recurrence the proca i life i study |
| topic | prostate cancer microRNA miR-24-1-5p radical prostatectomy biomarker population study |
| url | https://www.mdpi.com/2072-6694/14/5/1142 |
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