Antibodies Capable of Enhancing SARS-CoV-2 Infection Can Circulate in Patients with Severe COVID-19

Antibodies Capable of Enhancing SARS-CoV-2 Infection Can Circulate in Patients with Severe COVID-19

Antibody-dependent enhancement (ADE) has been shown previously for SARS-CoV-1, MERS-CoV, and SARS-CoV-2 infection in vitro. In this study, the first monoclonal antibody (mAb) that causes ADE in a SARS-CoV-2 in vivo model was identified. mAb RS2 against the SARS-CoV-2 S-protein was developed using hy...

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Bibliographic Details
Main Authors: Andrey Matveev, Oleg Pyankov, Yana Khlusevich, Olga Tyazhelkova, Lyudmila Emelyanova, Anna Timofeeva, Andrey Shipovalov, Anton Chechushkov, Natalia Zaitseva, Gleb Kudrov, Gaukhar Yusubalieva, Saule Yussubaliyeva, Oxana Zhukova, Vladimir Baklaushev, Sergey Sedykh, Galina Lifshits, Artem Tikunov, Nina Tikunova
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
COVID-19
SARS-CoV-2
antibody-dependent enhancement
monoclonal antibody
virus neutralizing antibody
ADE
Online Access:https://www.mdpi.com/1422-0067/24/13/10799

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