Plasma TIMP-1 as a sex-specific biomarker for acute lung injury
Highlights Plasma TIMP-1 levels are significantly elevated in ARDS patients. Plasma TIMP-1 levels show no difference between female and male ARDS patients. Considering the 30 and 90-day mortality, female non-survivors have significantly higher plasma TIMP-1 levels compared to female survivors. Howev...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-022-00481-9 |
| _version_ | 1811204207918710784 |
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| author | Sultan Almuntashiri Timothy W. Jones Xiaoyun Wang Andrea Sikora Duo Zhang |
| author_facet | Sultan Almuntashiri Timothy W. Jones Xiaoyun Wang Andrea Sikora Duo Zhang |
| author_sort | Sultan Almuntashiri |
| collection | DOAJ |
| description | Highlights Plasma TIMP-1 levels are significantly elevated in ARDS patients. Plasma TIMP-1 levels show no difference between female and male ARDS patients. Considering the 30 and 90-day mortality, female non-survivors have significantly higher plasma TIMP-1 levels compared to female survivors. However, there is no difference between non-survivors and survivors in the male group. Plasma TIMP-1 levels demonstrate an excellent discriminating ability for the prediction of mortality among female ARDS patients. The high TIMP-1 level group shows worse other relevant clinical outcomes, VFDs, and ICU-free days. |
| first_indexed | 2024-04-12T03:07:27Z |
| format | Article |
| id | doaj.art-a78b9d81d01641ae8e4c0c3a73312b8d |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-12T03:07:27Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-a78b9d81d01641ae8e4c0c3a73312b8d2022-12-22T03:50:27ZengBMCBiology of Sex Differences2042-64102022-12-011311910.1186/s13293-022-00481-9Plasma TIMP-1 as a sex-specific biomarker for acute lung injurySultan Almuntashiri0Timothy W. Jones1Xiaoyun Wang2Andrea Sikora3Duo Zhang4Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical CenterClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical CenterClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical CenterDepartment of Clinical and Administrative Pharmacy, College of Pharmacy, University of GeorgiaClinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical CenterHighlights Plasma TIMP-1 levels are significantly elevated in ARDS patients. Plasma TIMP-1 levels show no difference between female and male ARDS patients. Considering the 30 and 90-day mortality, female non-survivors have significantly higher plasma TIMP-1 levels compared to female survivors. However, there is no difference between non-survivors and survivors in the male group. Plasma TIMP-1 levels demonstrate an excellent discriminating ability for the prediction of mortality among female ARDS patients. The high TIMP-1 level group shows worse other relevant clinical outcomes, VFDs, and ICU-free days.https://doi.org/10.1186/s13293-022-00481-9Acute respiratory distress syndromeMortalityMatrix metalloproteinasesCritical illness |
| spellingShingle | Sultan Almuntashiri Timothy W. Jones Xiaoyun Wang Andrea Sikora Duo Zhang Plasma TIMP-1 as a sex-specific biomarker for acute lung injury Biology of Sex Differences Acute respiratory distress syndrome Mortality Matrix metalloproteinases Critical illness |
| title | Plasma TIMP-1 as a sex-specific biomarker for acute lung injury |
| title_full | Plasma TIMP-1 as a sex-specific biomarker for acute lung injury |
| title_fullStr | Plasma TIMP-1 as a sex-specific biomarker for acute lung injury |
| title_full_unstemmed | Plasma TIMP-1 as a sex-specific biomarker for acute lung injury |
| title_short | Plasma TIMP-1 as a sex-specific biomarker for acute lung injury |
| title_sort | plasma timp 1 as a sex specific biomarker for acute lung injury |
| topic | Acute respiratory distress syndrome Mortality Matrix metalloproteinases Critical illness |
| url | https://doi.org/10.1186/s13293-022-00481-9 |
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