Defining Structure‐Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra‐Stable Biopharmaceuticals

Abstract Biopharmaceuticals are the fastest‐growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and poloxamers are used to prevent protein aggregation, which sig...

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Main Authors: Alexander N. Prossnitz, Leslee T. Nguyen, Noah Eckman, Suraj Borkar, Samantha Tetef, Anton A. A. Autzen, Gerald G. Fuller, Eric A. Appel
格式: Article
語言:English
出版: Wiley 2025-02-01
叢編:Advanced Science
主題:
在線閱讀:https://doi.org/10.1002/advs.202409604