Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review
Abstract Background The physical challenges faced by adolescents and young adults (AYA) after a cancer diagnosis may be different from those experienced by paediatric and older adult cancer patients. Patient‐reported outcome measures (PROMs) are valuable tools that can be useful in exploring the exp...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.7046 |
| _version_ | 1797242768321413120 |
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| author | Sarah Tanner Teyl Engstrom Cheryl Forbes Dhaval Patel Wen Ray Lee Rick Walker Natalie Bradford Jason D. Pole |
| author_facet | Sarah Tanner Teyl Engstrom Cheryl Forbes Dhaval Patel Wen Ray Lee Rick Walker Natalie Bradford Jason D. Pole |
| author_sort | Sarah Tanner |
| collection | DOAJ |
| description | Abstract Background The physical challenges faced by adolescents and young adults (AYA) after a cancer diagnosis may be different from those experienced by paediatric and older adult cancer patients. Patient‐reported outcome measures (PROMs) are valuable tools that can be useful in exploring the experiences of AYAs and identifying important issues, recurrent themes and areas to potentially improve quality of life. Objective We compared patient‐reported physical function outcomes between AYAs diagnosed with cancer and non‐cancer controls. Method This paper builds on a scoping review published in early 2023 and focuses on PROMs related to physical function. Results This systematic review includes 16 studies that measured and reported on physical function PROMs in AYA cancer survivors compared with their cancer‐free peers. Of these studies, 14 found that physical function in AYA survivors was significantly worse. This paper also includes a meta‐analysis conducted on 5 studies using the EORTC‐QLQ‐C30 to measure physical function, which found that physical function score was an average of 7.03 (95% CI: −10.21, −3.86) points lower in the AYA cancer group, compared to their cancer free‐peers, a difference that is clinically meaningful. Conclusions The results overwhelmingly demonstrate that AYAs post a cancer diagnosis have worse health‐related quality of life from a physical function perspective than their cancer‐free peers, providing a compelling argument for the need to address this issue. All but one of the studies were cross‐sectional, which highlights the need for further assessment of this group longitudinally throughout their cancer journey. |
| first_indexed | 2024-04-24T18:44:28Z |
| format | Article |
| id | doaj.art-a78de6fd75a641a58157218d4643de37 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-24T18:44:28Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-a78de6fd75a641a58157218d4643de372024-03-27T07:32:40ZengWileyCancer Medicine2045-76342024-03-01136n/an/a10.1002/cam4.7046Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic reviewSarah Tanner0Teyl Engstrom1Cheryl Forbes2Dhaval Patel3Wen Ray Lee4Rick Walker5Natalie Bradford6Jason D. Pole7Centre for Health Services Research The University of Queensland Herston Queensland AustraliaCentre for Health Services Research The University of Queensland Herston Queensland AustraliaCentre for Health Services Research The University of Queensland Herston Queensland AustraliaCentre for Health Services Research The University of Queensland Herston Queensland AustraliaChild Health Research Centre The University of Queensland South Brisbane Queensland AustraliaSchool of Medicine The University of Queensland Herston Queensland AustraliaCancer and Palliative Care Outcomes Centre at Centre for Children's Health Research Queensland University of Technology Brisbane Queensland AustraliaCentre for Health Services Research The University of Queensland Herston Queensland AustraliaAbstract Background The physical challenges faced by adolescents and young adults (AYA) after a cancer diagnosis may be different from those experienced by paediatric and older adult cancer patients. Patient‐reported outcome measures (PROMs) are valuable tools that can be useful in exploring the experiences of AYAs and identifying important issues, recurrent themes and areas to potentially improve quality of life. Objective We compared patient‐reported physical function outcomes between AYAs diagnosed with cancer and non‐cancer controls. Method This paper builds on a scoping review published in early 2023 and focuses on PROMs related to physical function. Results This systematic review includes 16 studies that measured and reported on physical function PROMs in AYA cancer survivors compared with their cancer‐free peers. Of these studies, 14 found that physical function in AYA survivors was significantly worse. This paper also includes a meta‐analysis conducted on 5 studies using the EORTC‐QLQ‐C30 to measure physical function, which found that physical function score was an average of 7.03 (95% CI: −10.21, −3.86) points lower in the AYA cancer group, compared to their cancer free‐peers, a difference that is clinically meaningful. Conclusions The results overwhelmingly demonstrate that AYAs post a cancer diagnosis have worse health‐related quality of life from a physical function perspective than their cancer‐free peers, providing a compelling argument for the need to address this issue. All but one of the studies were cross‐sectional, which highlights the need for further assessment of this group longitudinally throughout their cancer journey.https://doi.org/10.1002/cam4.7046adolescentcancercancer survivorspatient‐reported outcome measuresphysical functionroutinely collected health data |
| spellingShingle | Sarah Tanner Teyl Engstrom Cheryl Forbes Dhaval Patel Wen Ray Lee Rick Walker Natalie Bradford Jason D. Pole Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review Cancer Medicine adolescent cancer cancer survivors patient‐reported outcome measures physical function routinely collected health data |
| title | Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review |
| title_full | Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review |
| title_fullStr | Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review |
| title_full_unstemmed | Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review |
| title_short | Physical function patient‐reported outcomes among adolescent and young adult cancer survivors: A systematic review |
| title_sort | physical function patient reported outcomes among adolescent and young adult cancer survivors a systematic review |
| topic | adolescent cancer cancer survivors patient‐reported outcome measures physical function routinely collected health data |
| url | https://doi.org/10.1002/cam4.7046 |
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