Intravitreal Anti-Vascular Endothelial Growth Factor for Macular Edema due to Complex Retinal Arterial Macroaneurysms
Introduction: Complex retinal arterial macroaneurysms (RAM) are often accompanied by hemorrhage and/or affect the macula. We evaluated the effect of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy using ranibizumab or aflibercept with or without laser photocoagulation in the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-03-01
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| Series: | Case Reports in Ophthalmology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/458517 |
| _version_ | 1818993049719537664 |
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| author | Caroline Bormann Jens Heichel Ute Hammer Anke Habermann Thomas Hammer |
| author_facet | Caroline Bormann Jens Heichel Ute Hammer Anke Habermann Thomas Hammer |
| author_sort | Caroline Bormann |
| collection | DOAJ |
| description | Introduction: Complex retinal arterial macroaneurysms (RAM) are often accompanied by hemorrhage and/or affect the macula. We evaluated the effect of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy using ranibizumab or aflibercept with or without laser photocoagulation in the treatment of macular edema due to RAM. Methods: A case report of two patients with secondary macular edema caused by RAM is presented. The first case was a 76-year-old female treated with two 0.5-mg injections of ranibizumab and additional focal laser photocoagulation. This patient presented a solely intraretinal exudation. The second patient was a 96-year-old female, who received one 2.0-mg injection of aflibercept. She showed sub- and intraretinal edema. We documented the clinical courses of these patients based on fundus photography, fluorescein angiography, and spectral-domain optical coherence tomography. Patients were followed-up for 12 months. Results: Patients were treated successfully using anti-VEGF therapy (ranibizumab or aflibercept) with or without laser photocoagulation. In both cases, we observed a complete regression of the macular edema and an increase in visual acuity. Conclusion: RAM can manifest with heterogeneous findings. Intravitreal anti-VEGF therapy with or without laser photocoagulation may be an effective treatment option in cases of macular edema due to RAM. Aflibercept and ranibizumab seem to be a potent anti-VEGF therapy for RAM. Individualized patient care is needed. |
| first_indexed | 2024-12-20T20:35:53Z |
| format | Article |
| id | doaj.art-a78e6a5eeaff463bbebf07387bb0010b |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-12-20T20:35:53Z |
| publishDate | 2017-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-a78e6a5eeaff463bbebf07387bb0010b2022-12-21T19:27:14ZengKarger PublishersCase Reports in Ophthalmology1663-26992017-03-018114114710.1159/000458517458517Intravitreal Anti-Vascular Endothelial Growth Factor for Macular Edema due to Complex Retinal Arterial MacroaneurysmsCaroline BormannJens HeichelUte HammerAnke HabermannThomas HammerIntroduction: Complex retinal arterial macroaneurysms (RAM) are often accompanied by hemorrhage and/or affect the macula. We evaluated the effect of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy using ranibizumab or aflibercept with or without laser photocoagulation in the treatment of macular edema due to RAM. Methods: A case report of two patients with secondary macular edema caused by RAM is presented. The first case was a 76-year-old female treated with two 0.5-mg injections of ranibizumab and additional focal laser photocoagulation. This patient presented a solely intraretinal exudation. The second patient was a 96-year-old female, who received one 2.0-mg injection of aflibercept. She showed sub- and intraretinal edema. We documented the clinical courses of these patients based on fundus photography, fluorescein angiography, and spectral-domain optical coherence tomography. Patients were followed-up for 12 months. Results: Patients were treated successfully using anti-VEGF therapy (ranibizumab or aflibercept) with or without laser photocoagulation. In both cases, we observed a complete regression of the macular edema and an increase in visual acuity. Conclusion: RAM can manifest with heterogeneous findings. Intravitreal anti-VEGF therapy with or without laser photocoagulation may be an effective treatment option in cases of macular edema due to RAM. Aflibercept and ranibizumab seem to be a potent anti-VEGF therapy for RAM. Individualized patient care is needed.http://www.karger.com/Article/FullText/458517RanibizumabRetinal arterial macroaneurysmAnti-vascular endothelial growth factorAfliberceptLaser photocoagulationMacular edema |
| spellingShingle | Caroline Bormann Jens Heichel Ute Hammer Anke Habermann Thomas Hammer Intravitreal Anti-Vascular Endothelial Growth Factor for Macular Edema due to Complex Retinal Arterial Macroaneurysms Case Reports in Ophthalmology Ranibizumab Retinal arterial macroaneurysm Anti-vascular endothelial growth factor Aflibercept Laser photocoagulation Macular edema |
| title | Intravitreal Anti-Vascular Endothelial Growth Factor for Macular Edema due to Complex Retinal Arterial Macroaneurysms |
| title_full | Intravitreal Anti-Vascular Endothelial Growth Factor for Macular Edema due to Complex Retinal Arterial Macroaneurysms |
| title_fullStr | Intravitreal Anti-Vascular Endothelial Growth Factor for Macular Edema due to Complex Retinal Arterial Macroaneurysms |
| title_full_unstemmed | Intravitreal Anti-Vascular Endothelial Growth Factor for Macular Edema due to Complex Retinal Arterial Macroaneurysms |
| title_short | Intravitreal Anti-Vascular Endothelial Growth Factor for Macular Edema due to Complex Retinal Arterial Macroaneurysms |
| title_sort | intravitreal anti vascular endothelial growth factor for macular edema due to complex retinal arterial macroaneurysms |
| topic | Ranibizumab Retinal arterial macroaneurysm Anti-vascular endothelial growth factor Aflibercept Laser photocoagulation Macular edema |
| url | http://www.karger.com/Article/FullText/458517 |
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