Evaluation of embryotoxic and teratogenic properties triclabendazole suspension
Objective of research: To investigate emryotoxic and teratogenic properties of anthelmintic «Triclabendazole suspension of 5%» on white outbred rats. Materials and methods: Experiments were conducted on 72 pregnant albino rats weighing 235-260 g that were divided into six groups: three experimental...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Scientific Centre VIEV
2019-10-01
|
| Series: | Российский паразитологический журнал |
| Subjects: | |
| Online Access: | https://vniigis.elpub.ru/jour/article/view/423 |
| _version_ | 1797270569894281216 |
|---|---|
| author | V. V. Napalkova N. P. Biryukova |
| author_facet | V. V. Napalkova N. P. Biryukova |
| author_sort | V. V. Napalkova |
| collection | DOAJ |
| description | Objective of research: To investigate emryotoxic and teratogenic properties of anthelmintic «Triclabendazole suspension of 5%» on white outbred rats. Materials and methods: Experiments were conducted on 72 pregnant albino rats weighing 235-260 g that were divided into six groups: three experimental (by 16 pregnant females each) and three control groups (8 pregnant females each). The rats from experimental groups were injected by suspension into the stomach at a dose of 36 mg/kg (3-fold therapeutic dose for cattle) in critical periods of embryogenesis as follows: 1 to 7 days of pregnancy (I group); 8 to 14 (II group) and from 1 to 19 days of pregnancy (III group). Control animals were injected with a physiological solution in an appropriate volume. Embryotoxic effect of the drug was evaluated by pre-implantation death of zygotes, and post-implantation death of embryos and total embryonic mortality. Teratogenic effect was estimated on organogenesis disorders in utero and changes in bone system of the fetus. Results and discussion: It was found that the general status and behavior of rats receiving the anthelmintic drug “Triclabendazole suspension 5%” at the dose of 36 mg a.i./kg remained without changes in all periods of pregnancy. The animals consumed food and water with pleasure, responded adequately to external stimuli. “Triclabendazole suspension 5%” at the dose of 36 mg a.i./kg as an intragastric injection applied during critical periods of pregnancy does not induce pre-implantation, post-implantation and total embryonic mortality, and does not cause organogenesis disorders in utero and changes in bone system of the fetus. |
| first_indexed | 2024-03-08T21:42:16Z |
| format | Article |
| id | doaj.art-a78e95c56a514b92a95326c5c65c976a |
| institution | Directory Open Access Journal |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| last_indexed | 2024-04-25T02:06:22Z |
| publishDate | 2019-10-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj.art-a78e95c56a514b92a95326c5c65c976a2024-03-07T14:34:25ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432019-10-01413277281420Evaluation of embryotoxic and teratogenic properties triclabendazole suspensionV. V. Napalkova0N. P. Biryukova1All-Federal state budgetary institution «The Russian state Center of quality and standardization medicines for animals and feed» (FGBI «VGNKI»)All-Federal state budgetary institution «The Russian state Center of quality and standardization medicines for animals and feed» (FGBI «VGNKI»)Objective of research: To investigate emryotoxic and teratogenic properties of anthelmintic «Triclabendazole suspension of 5%» on white outbred rats. Materials and methods: Experiments were conducted on 72 pregnant albino rats weighing 235-260 g that were divided into six groups: three experimental (by 16 pregnant females each) and three control groups (8 pregnant females each). The rats from experimental groups were injected by suspension into the stomach at a dose of 36 mg/kg (3-fold therapeutic dose for cattle) in critical periods of embryogenesis as follows: 1 to 7 days of pregnancy (I group); 8 to 14 (II group) and from 1 to 19 days of pregnancy (III group). Control animals were injected with a physiological solution in an appropriate volume. Embryotoxic effect of the drug was evaluated by pre-implantation death of zygotes, and post-implantation death of embryos and total embryonic mortality. Teratogenic effect was estimated on organogenesis disorders in utero and changes in bone system of the fetus. Results and discussion: It was found that the general status and behavior of rats receiving the anthelmintic drug “Triclabendazole suspension 5%” at the dose of 36 mg a.i./kg remained without changes in all periods of pregnancy. The animals consumed food and water with pleasure, responded adequately to external stimuli. “Triclabendazole suspension 5%” at the dose of 36 mg a.i./kg as an intragastric injection applied during critical periods of pregnancy does not induce pre-implantation, post-implantation and total embryonic mortality, and does not cause organogenesis disorders in utero and changes in bone system of the fetus.https://vniigis.elpub.ru/jour/article/view/423триклабендазолсуспензиякрысытератогенное и эмбриотоксическое действиеfascioliasissuspensionratsteratogenic and embryotoxic effects |
| spellingShingle | V. V. Napalkova N. P. Biryukova Evaluation of embryotoxic and teratogenic properties triclabendazole suspension Российский паразитологический журнал триклабендазол суспензия крысы тератогенное и эмбриотоксическое действие fascioliasis suspension rats teratogenic and embryotoxic effects |
| title | Evaluation of embryotoxic and teratogenic properties triclabendazole suspension |
| title_full | Evaluation of embryotoxic and teratogenic properties triclabendazole suspension |
| title_fullStr | Evaluation of embryotoxic and teratogenic properties triclabendazole suspension |
| title_full_unstemmed | Evaluation of embryotoxic and teratogenic properties triclabendazole suspension |
| title_short | Evaluation of embryotoxic and teratogenic properties triclabendazole suspension |
| title_sort | evaluation of embryotoxic and teratogenic properties triclabendazole suspension |
| topic | триклабендазол суспензия крысы тератогенное и эмбриотоксическое действие fascioliasis suspension rats teratogenic and embryotoxic effects |
| url | https://vniigis.elpub.ru/jour/article/view/423 |
| work_keys_str_mv | AT vvnapalkova evaluationofembryotoxicandteratogenicpropertiestriclabendazolesuspension AT npbiryukova evaluationofembryotoxicandteratogenicpropertiestriclabendazolesuspension |