Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold
Microneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles of pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO<sub>2</sub>-Si...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/10/1/65 |
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| author | Rio Yamagishi Sayaka Miura Kana Yabu Mano Ando Yuna Hachikubo Yoshiyuki Yokoyama Kaori Yasuda Satoshi Takei |
| author_facet | Rio Yamagishi Sayaka Miura Kana Yabu Mano Ando Yuna Hachikubo Yoshiyuki Yokoyama Kaori Yasuda Satoshi Takei |
| author_sort | Rio Yamagishi |
| collection | DOAJ |
| description | Microneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles of pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO<sub>2</sub>-SiO<sub>2</sub> gas-permeable mold polymerized by sol-gel hydrolysis reactions in nanoimprint lithography processes under refrigeration at 5 °C, where thermal decomposition of microneedle components can be avoided. The moldability, strength, and dissolution behavior of sodium hyaluronate hydrogels with different molecular weights were compared to evaluate the suitability of ultrafine microneedles with a bottom diameter of 40 μm and a height of 80 μm. The appropriate molecular weight range and formulation of pure sodium hyaluronate hydrogels were found to control the dissolution behavior of self-dissolving ultrafine microneedles while maintaining the moldability and strength of the microneedles. This fabrication technology of ultrafine microneedles expands their possibilities as a next-generation technique for bioactive gels for controlling the blood levels of drugs and avoiding pain during administration. |
| first_indexed | 2024-03-08T10:54:28Z |
| format | Article |
| id | doaj.art-a79145fed1e34f2a8ae79ba19c1bc013 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-08T10:54:28Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-a79145fed1e34f2a8ae79ba19c1bc0132024-01-26T16:40:28ZengMDPI AGGels2310-28612024-01-011016510.3390/gels10010065Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable MoldRio Yamagishi0Sayaka Miura1Kana Yabu2Mano Ando3Yuna Hachikubo4Yoshiyuki Yokoyama5Kaori Yasuda6Satoshi Takei7Graduate School of Biotechnology and Pharmaceutical Engineering, Toyama Prefectural University, Imizu 939-0398, Toyama, JapanGraduate School of Biotechnology and Pharmaceutical Engineering, Toyama Prefectural University, Imizu 939-0398, Toyama, JapanDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu 939-0398, Toyama, JapanDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu 939-0398, Toyama, JapanDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu 939-0398, Toyama, JapanToyama Industrial Technology Research and Development Center, Takaoka 933-0981, Toyama, JapanGraduate School of Biotechnology and Pharmaceutical Engineering, Toyama Prefectural University, Imizu 939-0398, Toyama, JapanGraduate School of Biotechnology and Pharmaceutical Engineering, Toyama Prefectural University, Imizu 939-0398, Toyama, JapanMicroneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles of pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO<sub>2</sub>-SiO<sub>2</sub> gas-permeable mold polymerized by sol-gel hydrolysis reactions in nanoimprint lithography processes under refrigeration at 5 °C, where thermal decomposition of microneedle components can be avoided. The moldability, strength, and dissolution behavior of sodium hyaluronate hydrogels with different molecular weights were compared to evaluate the suitability of ultrafine microneedles with a bottom diameter of 40 μm and a height of 80 μm. The appropriate molecular weight range and formulation of pure sodium hyaluronate hydrogels were found to control the dissolution behavior of self-dissolving ultrafine microneedles while maintaining the moldability and strength of the microneedles. This fabrication technology of ultrafine microneedles expands their possibilities as a next-generation technique for bioactive gels for controlling the blood levels of drugs and avoiding pain during administration.https://www.mdpi.com/2310-2861/10/1/65ultrafine microneedlessodium hyaluronatefunctional gelstransdermal drug delivery systemgas-permeable moldnanoimprint lithography |
| spellingShingle | Rio Yamagishi Sayaka Miura Kana Yabu Mano Ando Yuna Hachikubo Yoshiyuki Yokoyama Kaori Yasuda Satoshi Takei Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold Gels ultrafine microneedles sodium hyaluronate functional gels transdermal drug delivery system gas-permeable mold nanoimprint lithography |
| title | Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold |
| title_full | Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold |
| title_fullStr | Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold |
| title_full_unstemmed | Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold |
| title_short | Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold |
| title_sort | fabrication technology of self dissolving sodium hyaluronate gels ultrafine microneedles for medical applications with uv curing gas permeable mold |
| topic | ultrafine microneedles sodium hyaluronate functional gels transdermal drug delivery system gas-permeable mold nanoimprint lithography |
| url | https://www.mdpi.com/2310-2861/10/1/65 |
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