Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure
Background Poor cardiovascular health during pregnancy has been associated with adverse neurocognitive outcomes in the offspring. We examined the associations of maternal cardiovascular health factors with brain structure in 10‐year‐old children. Methods and Results We included 2797 mother–offspring...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.026133 |
| _version_ | 1797857436544008192 |
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| author | Carolina C. V. Silva Susana Santos Ryan L. Muetzel Meike W. Vernooij Bas B. van Rijn Vincent W. V. Jaddoe Hanan El Marroun |
| author_facet | Carolina C. V. Silva Susana Santos Ryan L. Muetzel Meike W. Vernooij Bas B. van Rijn Vincent W. V. Jaddoe Hanan El Marroun |
| author_sort | Carolina C. V. Silva |
| collection | DOAJ |
| description | Background Poor cardiovascular health during pregnancy has been associated with adverse neurocognitive outcomes in the offspring. We examined the associations of maternal cardiovascular health factors with brain structure in 10‐year‐old children. Methods and Results We included 2797 mother–offspring pairs from the Generation R Study. Maternal body mass index, gestational weight gain, blood pressure, insulin, glucose, and lipid blood concentrations were obtained in early pregnancy. Childhood structural brain measures, including global metrics of brain tissue volumes and white matter microstructure, were quantified by magnetic resonance imaging at 10 years. As compared with offspring of mothers with normal weight, those of mothers with underweight had smaller total brain volume (difference, −28.99 [95% CI −56.55 to −1.45] cm3). Similarly, as compared with offspring of mothers with gestational weight gain between the 25th and 75th percentile, those of mothers with gestational weight loss or no gestational weight gain (<25th percentile), had smaller total brain volume (difference, −13.07 [95% CI, −23.82 to −2.32] cm3). Also, higher maternal diastolic blood pressure in early pregnancy was associated with lower offspring white matter mean diffusivity (difference, −0.07 [95% CI, −0.11 to −0.02] SD score). After multiple testing correction, only the association of maternal diastolic blood pressure with lower offspring white matter mean diffusivity remained statistically significant. No associations were observed of maternal insulin, glucose, and lipid concentrations with childhood brain outcomes. Conclusions Our findings suggest that maternal cardiovascular health during pregnancy might be related to offspring brain development in the long term. Future studies are needed to replicate our findings and to explore the causal nature of the associations. |
| first_indexed | 2024-04-09T20:56:41Z |
| format | Article |
| id | doaj.art-a791b0efb8d843b9be72d39543784772 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-09T20:56:41Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-a791b0efb8d843b9be72d395437847722023-03-29T18:35:57ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-10-01111910.1161/JAHA.122.026133Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain StructureCarolina C. V. Silva0Susana Santos1Ryan L. Muetzel2Meike W. Vernooij3Bas B. van Rijn4Vincent W. V. Jaddoe5Hanan El Marroun6The Generation R Study Group, Erasmus MC University Medical Center Rotterdam Rotterdam The NetherlandsThe Generation R Study Group, Erasmus MC University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Radiology and Nuclear Medicine Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartments of Obstetrics and Gynecology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsThe Generation R Study Group, Erasmus MC University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Pediatrics Erasmus MC – Sophia Children’s Hospital, University Medical Center Rotterdam Rotterdam The NetherlandsBackground Poor cardiovascular health during pregnancy has been associated with adverse neurocognitive outcomes in the offspring. We examined the associations of maternal cardiovascular health factors with brain structure in 10‐year‐old children. Methods and Results We included 2797 mother–offspring pairs from the Generation R Study. Maternal body mass index, gestational weight gain, blood pressure, insulin, glucose, and lipid blood concentrations were obtained in early pregnancy. Childhood structural brain measures, including global metrics of brain tissue volumes and white matter microstructure, were quantified by magnetic resonance imaging at 10 years. As compared with offspring of mothers with normal weight, those of mothers with underweight had smaller total brain volume (difference, −28.99 [95% CI −56.55 to −1.45] cm3). Similarly, as compared with offspring of mothers with gestational weight gain between the 25th and 75th percentile, those of mothers with gestational weight loss or no gestational weight gain (<25th percentile), had smaller total brain volume (difference, −13.07 [95% CI, −23.82 to −2.32] cm3). Also, higher maternal diastolic blood pressure in early pregnancy was associated with lower offspring white matter mean diffusivity (difference, −0.07 [95% CI, −0.11 to −0.02] SD score). After multiple testing correction, only the association of maternal diastolic blood pressure with lower offspring white matter mean diffusivity remained statistically significant. No associations were observed of maternal insulin, glucose, and lipid concentrations with childhood brain outcomes. Conclusions Our findings suggest that maternal cardiovascular health during pregnancy might be related to offspring brain development in the long term. Future studies are needed to replicate our findings and to explore the causal nature of the associations.https://www.ahajournals.org/doi/10.1161/JAHA.122.026133blood pressurebrain structurecardiovascular healthmothersoffspring |
| spellingShingle | Carolina C. V. Silva Susana Santos Ryan L. Muetzel Meike W. Vernooij Bas B. van Rijn Vincent W. V. Jaddoe Hanan El Marroun Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease blood pressure brain structure cardiovascular health mothers offspring |
| title | Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure |
| title_full | Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure |
| title_fullStr | Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure |
| title_full_unstemmed | Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure |
| title_short | Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure |
| title_sort | maternal cardiovascular health in early pregnancy and childhood brain structure |
| topic | blood pressure brain structure cardiovascular health mothers offspring |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.026133 |
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