The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issues
Increasing attention in rheumatology is today paid to the detection of diseases at the earliest possible (preclinical) stages, which can contribute to a more favorable response to therapy. The preclinical period of a systemic autoimmune reaction is assumed to be related to dysregulation of immune in...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2021-02-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1094 |
| _version_ | 1826556856572575744 |
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| author | A. M. Lila E. A. Galushko A. V. Gordeev A. S. Semashko |
| author_facet | A. M. Lila E. A. Galushko A. V. Gordeev A. S. Semashko |
| author_sort | A. M. Lila |
| collection | DOAJ |
| description | Increasing attention in rheumatology is today paid to the detection of diseases at the earliest possible (preclinical) stages, which can contribute to a more favorable response to therapy. The preclinical period of a systemic autoimmune reaction is assumed to be related to dysregulation of immune interactions with the synanthropic microflora. A sequencing method was used to study deviations in the diversity of the gut microflora in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. However, a number of unresolved issues remain, since the emphasis has been on the cataloguing of the microorganisms present and on the identification of correlations between microbial species and diseases. The main difference in future microbiome research in patients with immune-mediated inflammatory diseases should be a closer examination of the functions of microbiota components, and not just their description. Long-term studies with the collection of intestinal microbiome samples are required at several time intervals: before disease-modifying antirheumatic drug therapy and during ineffective therapy. Such studies will contribute to the development of new diagnostic and therapeutic interventions. Until they are completed, it is untimely to recommend microbiome analysis as a diagnostic or prognostic tool for the management of rheumatic diseases in clinical practice. |
| first_indexed | 2024-04-10T02:06:38Z |
| format | Article |
| id | doaj.art-a7948991e99141688f02ce515ab5ce73 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2025-03-14T08:19:21Z |
| publishDate | 2021-02-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-a7948991e99141688f02ce515ab5ce732025-03-02T13:11:04ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2021-02-01151151910.14412/1996-7012-2021-1-15-192317The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issuesA. M. Lila0E. A. Galushko1A. V. Gordeev2A. S. Semashko3V.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyIncreasing attention in rheumatology is today paid to the detection of diseases at the earliest possible (preclinical) stages, which can contribute to a more favorable response to therapy. The preclinical period of a systemic autoimmune reaction is assumed to be related to dysregulation of immune interactions with the synanthropic microflora. A sequencing method was used to study deviations in the diversity of the gut microflora in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. However, a number of unresolved issues remain, since the emphasis has been on the cataloguing of the microorganisms present and on the identification of correlations between microbial species and diseases. The main difference in future microbiome research in patients with immune-mediated inflammatory diseases should be a closer examination of the functions of microbiota components, and not just their description. Long-term studies with the collection of intestinal microbiome samples are required at several time intervals: before disease-modifying antirheumatic drug therapy and during ineffective therapy. Such studies will contribute to the development of new diagnostic and therapeutic interventions. Until they are completed, it is untimely to recommend microbiome analysis as a diagnostic or prognostic tool for the management of rheumatic diseases in clinical practice.https://mrj.ima-press.net/mrj/article/view/1094microbiotasequencingrheumatoid arthritisspondyloarthritis |
| spellingShingle | A. M. Lila E. A. Galushko A. V. Gordeev A. S. Semashko The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issues Современная ревматология microbiota sequencing rheumatoid arthritis spondyloarthritis |
| title | The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issues |
| title_full | The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issues |
| title_fullStr | The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issues |
| title_full_unstemmed | The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issues |
| title_short | The role of microbiome in the pathogenesis of immune-mediated inflammatory diseases: controversial issues |
| title_sort | role of microbiome in the pathogenesis of immune mediated inflammatory diseases controversial issues |
| topic | microbiota sequencing rheumatoid arthritis spondyloarthritis |
| url | https://mrj.ima-press.net/mrj/article/view/1094 |
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