Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia
Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the cell cycle and differentiation in the myeloid lineag...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Hemato |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-6357/2/3/35 |
| _version_ | 1797519071154012160 |
|---|---|
| author | Shaun D. Patterson Xu Huang Heather G. Jørgensen Alison M. Michie |
| author_facet | Shaun D. Patterson Xu Huang Heather G. Jørgensen Alison M. Michie |
| author_sort | Shaun D. Patterson |
| collection | DOAJ |
| description | Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the cell cycle and differentiation in the myeloid lineage. Recent evidence has demonstrated that NFAT family members may have roles in regulating AML leukemogenesis and resistance to targeted therapy in myeloid leukaemia. Furthermore, gene expression data from patient samples show that some NFATs are more highly expressed in poorly differentiated AML and after disease relapse, implying that the NFAT family may have roles in specific types of AML. This review outlines the evidence for the role of NFAT in healthy myeloid tissue and explores how NFAT might regulate AML pathogenesis, highlighting the potential to target specific NFAT proteins therapeutically in AML. |
| first_indexed | 2024-03-10T07:37:59Z |
| format | Article |
| id | doaj.art-a7948ca22b954a4a96da1c9551126150 |
| institution | Directory Open Access Journal |
| issn | 2673-6357 |
| language | English |
| last_indexed | 2024-03-10T07:37:59Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hemato |
| spelling | doaj.art-a7948ca22b954a4a96da1c95511261502023-11-22T13:19:24ZengMDPI AGHemato2673-63572021-08-012355657110.3390/hemato2030035Transcriptional Regulation by the NFAT Family in Acute Myeloid LeukaemiaShaun D. Patterson0Xu Huang1Heather G. Jørgensen2Alison M. Michie3Paul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of MVLS, University of Glasgow, Glasgow G120ZD, UKPaul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of MVLS, University of Glasgow, Glasgow G120ZD, UKPaul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of MVLS, University of Glasgow, Glasgow G120ZD, UKPaul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of MVLS, University of Glasgow, Glasgow G120ZD, UKAcute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the cell cycle and differentiation in the myeloid lineage. Recent evidence has demonstrated that NFAT family members may have roles in regulating AML leukemogenesis and resistance to targeted therapy in myeloid leukaemia. Furthermore, gene expression data from patient samples show that some NFATs are more highly expressed in poorly differentiated AML and after disease relapse, implying that the NFAT family may have roles in specific types of AML. This review outlines the evidence for the role of NFAT in healthy myeloid tissue and explores how NFAT might regulate AML pathogenesis, highlighting the potential to target specific NFAT proteins therapeutically in AML.https://www.mdpi.com/2673-6357/2/3/35leukaemiaNFATmyeloidcell cycledifferentiationAML |
| spellingShingle | Shaun D. Patterson Xu Huang Heather G. Jørgensen Alison M. Michie Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia Hemato leukaemia NFAT myeloid cell cycle differentiation AML |
| title | Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia |
| title_full | Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia |
| title_fullStr | Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia |
| title_full_unstemmed | Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia |
| title_short | Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia |
| title_sort | transcriptional regulation by the nfat family in acute myeloid leukaemia |
| topic | leukaemia NFAT myeloid cell cycle differentiation AML |
| url | https://www.mdpi.com/2673-6357/2/3/35 |
| work_keys_str_mv | AT shaundpatterson transcriptionalregulationbythenfatfamilyinacutemyeloidleukaemia AT xuhuang transcriptionalregulationbythenfatfamilyinacutemyeloidleukaemia AT heathergjørgensen transcriptionalregulationbythenfatfamilyinacutemyeloidleukaemia AT alisonmmichie transcriptionalregulationbythenfatfamilyinacutemyeloidleukaemia |