Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases

Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases

The mammalian 14-3-3 family comprises seven intrinsically unstructured, evolutionarily conserved proteins that bind >200 protein targets, thereby modulating cell-signaling pathways. The presence of 14-3-3 proteins in cerebrospinal fluid provides a sensitive and specific biomarker of neuronal dama...

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Bibliographic Details
Main Authors:	Akshatha Ganne, Meenakshisundaram Balasubramaniam, Nirjal Mainali, Paavan Atluri, Robert J. Shmookler Reis, Srinivas Ayyadevara
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	International Journal of Molecular Sciences
Subjects:	protein aggregation Alzheimer’s disease neurodegeneration PPII drugs 14-3-3 hexokinase
Online Access:	https://www.mdpi.com/1422-0067/23/24/15457

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