New Insights on the Nuclear Functions and Targeting of FAK in Cancer

New Insights on the Nuclear Functions and Targeting of FAK in Cancer

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase over-expressed and activated in both adult and pediatric cancers, where it plays important roles in the regulation of pathogenesis and progression of the malignant phenotype. FAK exerts its functions in cancer by two different ways: a kin...

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Bibliographic Details
Main Authors: Silvia Pomella, Matteo Cassandri, Maria Rita Braghini, Francesco Marampon, Anna Alisi, Rossella Rota
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
FAK
adult cancers
pediatric cancers
targeted therapy
combination therapy
PROTACs
Online Access:https://www.mdpi.com/1422-0067/23/4/1998

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