Diagnosis of isolated cardiac sarcoidosis based on new guidelines
Abstract Aims In the updated guidelines for cardiac sarcoidosis (CS) proposed by the Japanese Circulation Society (JCS), the definition of isolated CS (iCS) was established for the first time. This prompted us to examine the characteristics of patients with CS including iCS according to them by revi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.12853 |
| _version_ | 1818915446853730304 |
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| author | Hideki Kawai Masayoshi Sarai Yasuchika Kato Hiroyuki Naruse Ayumi Watanabe Takahiro Matsuyama Hiroshi Takahashi Sadako Motoyama Junnichi Ishii Shin‐ichiro Morimoto Hiroshi Toyama Yukio Ozaki |
| author_facet | Hideki Kawai Masayoshi Sarai Yasuchika Kato Hiroyuki Naruse Ayumi Watanabe Takahiro Matsuyama Hiroshi Takahashi Sadako Motoyama Junnichi Ishii Shin‐ichiro Morimoto Hiroshi Toyama Yukio Ozaki |
| author_sort | Hideki Kawai |
| collection | DOAJ |
| description | Abstract Aims In the updated guidelines for cardiac sarcoidosis (CS) proposed by the Japanese Circulation Society (JCS), the definition of isolated CS (iCS) was established for the first time. This prompted us to examine the characteristics of patients with CS including iCS according to them by reviewing patients undergoing 18F‐fluoro‐2‐deoxyglucose positron‐emission tomography/computerized tomography (FDG‐PET/CT), compared with those with CS determined by the conventional international criteria. Methods and results From 2013 to 2019, 94 patients (61 ± 15 years, 50 female patients) with suspected CS underwent whole‐body and cardiac FDG‐PET/CT scanning. In contrast to 22 patients with CS based on the international criteria, 34 [27 with systemic sarcoidosis including cardiac involvement (sCS) and 7 with clinical iCS] were diagnosed with CS according to the new JCS guidelines (P = 0.012), and 60 were not (4 suspected iCS, 13 systematic sarcoidosis without cardiac involvement, and 43 no sarcoidosis). In addition to 26 of 34 patients with CS, corticosteroids were also started in 6 of 60 without CS according to clinical need. Conclusions Diagnostic yield with the new JCS guidelines was higher, with approximately 1.5‐fold of the patients diagnosed with CS compared with the previous international criteria and clinical iCS accounting for approximately 20% of the whole CS cohort. In addition to 75% of the patients with sCS or clinical iCS in the updated guidelines, 10% in whom CS was not documented were also started on corticosteroids for clinical indications such as reduced cardiac function or arrhythmia. |
| first_indexed | 2024-12-20T00:02:25Z |
| format | Article |
| id | doaj.art-a797fe574e254e8fb93b2a9cf8094e3a |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-20T00:02:25Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-a797fe574e254e8fb93b2a9cf8094e3a2022-12-21T20:00:47ZengWileyESC Heart Failure2055-58222020-10-01752662267110.1002/ehf2.12853Diagnosis of isolated cardiac sarcoidosis based on new guidelinesHideki Kawai0Masayoshi Sarai1Yasuchika Kato2Hiroyuki Naruse3Ayumi Watanabe4Takahiro Matsuyama5Hiroshi Takahashi6Sadako Motoyama7Junnichi Ishii8Shin‐ichiro Morimoto9Hiroshi Toyama10Yukio Ozaki11Department of Cardiology Fujita Health University 1‐98 Dengakugakubo Toyoake JapanDepartment of Cardiology Fujita Health University 1‐98 Dengakugakubo Toyoake JapanDepartment of Cardiology Fujita Health University 1‐98 Dengakugakubo Toyoake JapanDepartment of Cardiology Fujita Health University 1‐98 Dengakugakubo Toyoake JapanDepartment of Radiology Fujita Health University Toyoake JapanDepartment of Radiology Fujita Health University Toyoake JapanDivision of Statistics Fujita Health University Toyoake JapanDepartment of Cardiology Fujita Health University 1‐98 Dengakugakubo Toyoake JapanDepartment of Cardiology Fujita Health University 1‐98 Dengakugakubo Toyoake JapanDepartment of Cardiology Fujita Health University 1‐98 Dengakugakubo Toyoake JapanDepartment of Radiology Fujita Health University Toyoake JapanDepartment of Cardiology Fujita Health University 1‐98 Dengakugakubo Toyoake JapanAbstract Aims In the updated guidelines for cardiac sarcoidosis (CS) proposed by the Japanese Circulation Society (JCS), the definition of isolated CS (iCS) was established for the first time. This prompted us to examine the characteristics of patients with CS including iCS according to them by reviewing patients undergoing 18F‐fluoro‐2‐deoxyglucose positron‐emission tomography/computerized tomography (FDG‐PET/CT), compared with those with CS determined by the conventional international criteria. Methods and results From 2013 to 2019, 94 patients (61 ± 15 years, 50 female patients) with suspected CS underwent whole‐body and cardiac FDG‐PET/CT scanning. In contrast to 22 patients with CS based on the international criteria, 34 [27 with systemic sarcoidosis including cardiac involvement (sCS) and 7 with clinical iCS] were diagnosed with CS according to the new JCS guidelines (P = 0.012), and 60 were not (4 suspected iCS, 13 systematic sarcoidosis without cardiac involvement, and 43 no sarcoidosis). In addition to 26 of 34 patients with CS, corticosteroids were also started in 6 of 60 without CS according to clinical need. Conclusions Diagnostic yield with the new JCS guidelines was higher, with approximately 1.5‐fold of the patients diagnosed with CS compared with the previous international criteria and clinical iCS accounting for approximately 20% of the whole CS cohort. In addition to 75% of the patients with sCS or clinical iCS in the updated guidelines, 10% in whom CS was not documented were also started on corticosteroids for clinical indications such as reduced cardiac function or arrhythmia.https://doi.org/10.1002/ehf2.12853Cardiac sarcoidosisFluorine‐18‐fluorodeoxyglucose positron emission tomographyIsolated cardiac sarcoidosis |
| spellingShingle | Hideki Kawai Masayoshi Sarai Yasuchika Kato Hiroyuki Naruse Ayumi Watanabe Takahiro Matsuyama Hiroshi Takahashi Sadako Motoyama Junnichi Ishii Shin‐ichiro Morimoto Hiroshi Toyama Yukio Ozaki Diagnosis of isolated cardiac sarcoidosis based on new guidelines ESC Heart Failure Cardiac sarcoidosis Fluorine‐18‐fluorodeoxyglucose positron emission tomography Isolated cardiac sarcoidosis |
| title | Diagnosis of isolated cardiac sarcoidosis based on new guidelines |
| title_full | Diagnosis of isolated cardiac sarcoidosis based on new guidelines |
| title_fullStr | Diagnosis of isolated cardiac sarcoidosis based on new guidelines |
| title_full_unstemmed | Diagnosis of isolated cardiac sarcoidosis based on new guidelines |
| title_short | Diagnosis of isolated cardiac sarcoidosis based on new guidelines |
| title_sort | diagnosis of isolated cardiac sarcoidosis based on new guidelines |
| topic | Cardiac sarcoidosis Fluorine‐18‐fluorodeoxyglucose positron emission tomography Isolated cardiac sarcoidosis |
| url | https://doi.org/10.1002/ehf2.12853 |
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