Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

T cell-driven inflammation plays a critical role in the initiation and progression of atherosclerosis. The co-inhibitory protein Cytotoxic T-Lymphocyte Associated protein (CTLA) 4 is an important negative regulator of T cell activation. Here, we studied the effects of the antibody-mediated inhibitio...

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Bibliographic Details
Main Authors: Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
atherosclerosis
Cytotoxic T-Lymphocyte Associated protein (CTLA) 4
T cells
inflammation
immune checkpoint inhibitors
Online Access:https://www.mdpi.com/2073-4409/9/9/1987

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