Disseminated cutaneous trichosporonosis in an adult bone marrow transplant patient
The Trichosporon species are yeast-like opportunistic pathogens in immunocompromised patients. Trichosporon asahii infections have been reported in pediatric bone marrow transplant (BMT) patients. However, its incidence is low in the adult literature. A 52-year-old Chinese woman who was diagnosed wi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Dermatology Online Journal |
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| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2017;volume=8;issue=3;spage=192;epage=194;aulast=Yong |
| _version_ | 1819089907486818304 |
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| author | A. M. Y. Yong S S Yang K B Tan S A Ho |
| author_facet | A. M. Y. Yong S S Yang K B Tan S A Ho |
| author_sort | A. M. Y. Yong |
| collection | DOAJ |
| description | The Trichosporon species are yeast-like opportunistic pathogens in immunocompromised patients. Trichosporon asahii infections have been reported in pediatric bone marrow transplant (BMT) patients. However, its incidence is low in the adult literature. A 52-year-old Chinese woman who was diagnosed with acute myeloid leukemia received induction chemotherapy and underwent allogenic bone marrow transplant, which was complicated by a relapse and required salvage chemotherapy. She developed persistent non-neutropenic fever secondary to presumed hepatosplenic candidiasis. Antifungal therapy with fluconazole and anidulafungin was administered. She remained febrile and tender dusky nodules appeared over all the four limbs. Histopathological examination and fungal culture identified T. asahii. Oral voriconazole was initiated with complete resolution of her lesions. The Trichosporon species is a frequently isolated yeast species from cancer patients. Voriconazole has become the first choice agent against Trichosporon. We highlight the increased awareness and clinical suspicion required for diagnosis and subsequent management in similar adult patients. |
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| format | Article |
| id | doaj.art-a79a4c38ce4d45828dcd7b6b86b2ef82 |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-21T22:15:23Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-a79a4c38ce4d45828dcd7b6b86b2ef822022-12-21T18:48:28ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782017-01-018319219410.4103/idoj.IDOJ_92_16Disseminated cutaneous trichosporonosis in an adult bone marrow transplant patientA. M. Y. YongS S YangK B TanS A HoThe Trichosporon species are yeast-like opportunistic pathogens in immunocompromised patients. Trichosporon asahii infections have been reported in pediatric bone marrow transplant (BMT) patients. However, its incidence is low in the adult literature. A 52-year-old Chinese woman who was diagnosed with acute myeloid leukemia received induction chemotherapy and underwent allogenic bone marrow transplant, which was complicated by a relapse and required salvage chemotherapy. She developed persistent non-neutropenic fever secondary to presumed hepatosplenic candidiasis. Antifungal therapy with fluconazole and anidulafungin was administered. She remained febrile and tender dusky nodules appeared over all the four limbs. Histopathological examination and fungal culture identified T. asahii. Oral voriconazole was initiated with complete resolution of her lesions. The Trichosporon species is a frequently isolated yeast species from cancer patients. Voriconazole has become the first choice agent against Trichosporon. We highlight the increased awareness and clinical suspicion required for diagnosis and subsequent management in similar adult patients.http://www.idoj.in/article.asp?issn=2229-5178;year=2017;volume=8;issue=3;spage=192;epage=194;aulast=YongImmunocompromised hostopportunistic infectionsTrichosporon asahiivoriconazole |
| spellingShingle | A. M. Y. Yong S S Yang K B Tan S A Ho Disseminated cutaneous trichosporonosis in an adult bone marrow transplant patient Indian Dermatology Online Journal Immunocompromised host opportunistic infections Trichosporon asahii voriconazole |
| title | Disseminated cutaneous trichosporonosis in an adult bone marrow transplant patient |
| title_full | Disseminated cutaneous trichosporonosis in an adult bone marrow transplant patient |
| title_fullStr | Disseminated cutaneous trichosporonosis in an adult bone marrow transplant patient |
| title_full_unstemmed | Disseminated cutaneous trichosporonosis in an adult bone marrow transplant patient |
| title_short | Disseminated cutaneous trichosporonosis in an adult bone marrow transplant patient |
| title_sort | disseminated cutaneous trichosporonosis in an adult bone marrow transplant patient |
| topic | Immunocompromised host opportunistic infections Trichosporon asahii voriconazole |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2017;volume=8;issue=3;spage=192;epage=194;aulast=Yong |
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