Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering
Abstract The increasing prevalence of orthopedic‐related diseases necessitates the development of effective orthopedic implants. Conventional metal scaffolds used in orthopedic devices have limitations such as poor biocompatibility and the need for a second surgery to remove the scaffold. Degradable...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | MedComm – Biomaterials and Applications |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mba2.60 |
| _version_ | 1797390299106902016 |
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| author | Jian He Kun Li Tingkui Wu Jiafang Chen Sanqiang Li Xiangchun Zhang |
| author_facet | Jian He Kun Li Tingkui Wu Jiafang Chen Sanqiang Li Xiangchun Zhang |
| author_sort | Jian He |
| collection | DOAJ |
| description | Abstract The increasing prevalence of orthopedic‐related diseases necessitates the development of effective orthopedic implants. Conventional metal scaffolds used in orthopedic devices have limitations such as poor biocompatibility and the need for a second surgery to remove the scaffold. Degradable metal‐based scaffolds, including metal‐based scaffolds and multifunctional scaffolds doped with metal elements, are a rapidly developing tissue engineering strategy aimed at utilizing the mechanical and biological properties of metal elements to create a support structure that matches the complex bone regeneration environment. Repairing bone defects involves the regeneration of various tissues, and incomplete repair can negatively affect bone function and overall recovery. Therefore, combining metal‐based degradable materials with other active components has great potential for enhancing the versatility and clinical applications of scaffolds. Multifunctional scaffolds doped with metal elements have better biocompatibility, osteoinductivity, biodegradability, matching mechanical, and microenvironmental adjustment capabilities. Moreover, these metal‐doped scaffolds possess the advantages of controlled release of metal ions, multifunctionality, and faster degradation. This review focuses on the materials and techniques used for constructing degradable metal‐based scaffolds. Furthermore, this study discussed the potential for designing and constructing multifunctional biodegradable metal‐based scaffolds doped with metal elements by integrating multiple strategies. |
| first_indexed | 2024-03-08T23:08:47Z |
| format | Article |
| id | doaj.art-a79a9809540e4dd9811a01fde1044625 |
| institution | Directory Open Access Journal |
| issn | 2769-643X |
| language | English |
| last_indexed | 2024-03-08T23:08:47Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Biomaterials and Applications |
| spelling | doaj.art-a79a9809540e4dd9811a01fde10446252023-12-15T09:32:41ZengWileyMedComm – Biomaterials and Applications2769-643X2023-12-0124n/an/a10.1002/mba2.60Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineeringJian He0Kun Li1Tingkui Wu2Jiafang Chen3Sanqiang Li4Xiangchun Zhang5College of Basic Medicine and Forensic Medicine Henan University of Science and Technology Luoyang ChinaDepartment of General Surgery Fuyang Tumor Hospital Fuyang ChinaDepartment of Orthopedic Surgery West China Hospital of Sichuan University Chengdu ChinaCollege of Basic Medicine and Forensic Medicine Henan University of Science and Technology Luoyang ChinaCollege of Basic Medicine and Forensic Medicine Henan University of Science and Technology Luoyang ChinaTea Research Institute Chinese Academy of Agricultural Sciences Hangzhou ChinaAbstract The increasing prevalence of orthopedic‐related diseases necessitates the development of effective orthopedic implants. Conventional metal scaffolds used in orthopedic devices have limitations such as poor biocompatibility and the need for a second surgery to remove the scaffold. Degradable metal‐based scaffolds, including metal‐based scaffolds and multifunctional scaffolds doped with metal elements, are a rapidly developing tissue engineering strategy aimed at utilizing the mechanical and biological properties of metal elements to create a support structure that matches the complex bone regeneration environment. Repairing bone defects involves the regeneration of various tissues, and incomplete repair can negatively affect bone function and overall recovery. Therefore, combining metal‐based degradable materials with other active components has great potential for enhancing the versatility and clinical applications of scaffolds. Multifunctional scaffolds doped with metal elements have better biocompatibility, osteoinductivity, biodegradability, matching mechanical, and microenvironmental adjustment capabilities. Moreover, these metal‐doped scaffolds possess the advantages of controlled release of metal ions, multifunctionality, and faster degradation. This review focuses on the materials and techniques used for constructing degradable metal‐based scaffolds. Furthermore, this study discussed the potential for designing and constructing multifunctional biodegradable metal‐based scaffolds doped with metal elements by integrating multiple strategies.https://doi.org/10.1002/mba2.60bone regenerationdegradable metal‐based scaffoldsmultifunctional |
| spellingShingle | Jian He Kun Li Tingkui Wu Jiafang Chen Sanqiang Li Xiangchun Zhang Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering MedComm – Biomaterials and Applications bone regeneration degradable metal‐based scaffolds multifunctional |
| title | Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering |
| title_full | Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering |
| title_fullStr | Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering |
| title_full_unstemmed | Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering |
| title_short | Research progress in degradable metal‐based multifunctional scaffolds for bone tissue engineering |
| title_sort | research progress in degradable metal based multifunctional scaffolds for bone tissue engineering |
| topic | bone regeneration degradable metal‐based scaffolds multifunctional |
| url | https://doi.org/10.1002/mba2.60 |
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