The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation
Objective To explore the influence of apolipoprotein E ( APOE ) genotypes and blood lipid metabolism on coronary artery disease (CAD) with atrial fibrillation (AF). Methods Patients with suspected CAD were consecutively enrolled and divided into groups with or without CAD and/or AF. Blood lipid leve...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-07-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221109387 |
| _version_ | 1818478156112199680 |
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| author | Yong Li Lei Chen Yameng Shao Min Zhang Li Zhi Yuan Lu |
| author_facet | Yong Li Lei Chen Yameng Shao Min Zhang Li Zhi Yuan Lu |
| author_sort | Yong Li |
| collection | DOAJ |
| description | Objective To explore the influence of apolipoprotein E ( APOE ) genotypes and blood lipid metabolism on coronary artery disease (CAD) with atrial fibrillation (AF). Methods Patients with suspected CAD were consecutively enrolled and divided into groups with or without CAD and/or AF. Blood lipid levels and APOE genotypes were determined and analysed for associations with CAD and AF. Results A total of 2048 patients were included (400 patients without CAD or AF [controls], 126 patients without CAD but with AF, 1294 patients with CAD without AF, and 228 patients with CAD and AF). Age and lipoprotein (a) (Lp[a]) levels were significantly higher in patients with CAD and AF versus those with CAD without AF. Among patients with CAD, the E3/E3 genotype and ε3 allele frequencies were significantly lower in patients with AF than in those without AF, and the E4/E4 genotype and ε4 allele frequencies were significantly increased. Multivariate logistic regression revealed that increased Lp(a) levels and age were independent risk factors for AF in patients with CAD. Conclusion Among patients with CAD, those with AF had increased age, ε4 frequencies and Lp(a) levels. Age and Lp(a) levels may be independent risk factors for AF in patients with CAD. |
| first_indexed | 2024-12-10T09:44:48Z |
| format | Article |
| id | doaj.art-a79ae43725f448b2bf406ee3144c91d9 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-10T09:44:48Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-a79ae43725f448b2bf406ee3144c91d92022-12-22T01:53:53ZengSAGE PublishingJournal of International Medical Research1473-23002022-07-015010.1177/03000605221109387The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillationYong LiLei ChenYameng ShaoMin ZhangLi ZhiYuan LuObjective To explore the influence of apolipoprotein E ( APOE ) genotypes and blood lipid metabolism on coronary artery disease (CAD) with atrial fibrillation (AF). Methods Patients with suspected CAD were consecutively enrolled and divided into groups with or without CAD and/or AF. Blood lipid levels and APOE genotypes were determined and analysed for associations with CAD and AF. Results A total of 2048 patients were included (400 patients without CAD or AF [controls], 126 patients without CAD but with AF, 1294 patients with CAD without AF, and 228 patients with CAD and AF). Age and lipoprotein (a) (Lp[a]) levels were significantly higher in patients with CAD and AF versus those with CAD without AF. Among patients with CAD, the E3/E3 genotype and ε3 allele frequencies were significantly lower in patients with AF than in those without AF, and the E4/E4 genotype and ε4 allele frequencies were significantly increased. Multivariate logistic regression revealed that increased Lp(a) levels and age were independent risk factors for AF in patients with CAD. Conclusion Among patients with CAD, those with AF had increased age, ε4 frequencies and Lp(a) levels. Age and Lp(a) levels may be independent risk factors for AF in patients with CAD.https://doi.org/10.1177/03000605221109387 |
| spellingShingle | Yong Li Lei Chen Yameng Shao Min Zhang Li Zhi Yuan Lu The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation Journal of International Medical Research |
| title | The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation |
| title_full | The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation |
| title_fullStr | The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation |
| title_full_unstemmed | The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation |
| title_short | The effect of apolipoprotein E gene polymorphism and Lp(a) levels on coronary artery disease with atrial fibrillation |
| title_sort | effect of apolipoprotein e gene polymorphism and lp a levels on coronary artery disease with atrial fibrillation |
| url | https://doi.org/10.1177/03000605221109387 |
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