Systematic review of computational modelling for biomechanics analysis of total knee replacement

In vitro and in vivo testing can provide insight into knee joint mechanics and implant performance. However, these methods are costly and time-consuming, which always limits their widespread use during the design stage of the implant. This review presents a critical analysis of computational modelli...

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Main Authors: Liming Shu, Shihao Li, Naohiko Sugita
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Biosurface and Biotribology
Subjects:
Online Access:https://digital-library.theiet.org/content/journals/10.1049/bsbt.2019.0012
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author Liming Shu
Shihao Li
Shihao Li
Naohiko Sugita
author_facet Liming Shu
Shihao Li
Shihao Li
Naohiko Sugita
author_sort Liming Shu
collection DOAJ
description In vitro and in vivo testing can provide insight into knee joint mechanics and implant performance. However, these methods are costly and time-consuming, which always limits their widespread use during the design stage of the implant. This review presents a critical analysis of computational modelling (in-silicon) techniques including (i) development of a generic model of total knee replacement (TKR) and application of material properties, loading, and boundary conditions; (ii) design and execution of computational experiments; and (iii) practical applications and significant findings. The results show that the generic model and techniques provide significant insight into the general performance of TKR but have limited explicit validation. The introduction of design-of-experiments, probabilistic, and neural network methodologies in computational modelling has enabled simulation at the population level. Further advances in subjective modelling appear to be limited, mainly because of the lack of subjective materials and boundary conditions. Computational modelling will increasingly be used in the preclinical testing and design of TKR. This modelling should include subjective, multi-scale, and closely corroborated analyses to account for the variability of TKR.
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spelling doaj.art-a79d81cce6e34df2a3a94b38ec0ce5122022-12-21T23:44:33ZengWileyBiosurface and Biotribology2405-45182020-02-0110.1049/bsbt.2019.0012BSBT.2019.0012Systematic review of computational modelling for biomechanics analysis of total knee replacementLiming Shu0Shihao Li1Shihao Li2Naohiko Sugita3School of Engineering, The University of TokyoSchool of Engineering, The University of TokyoSchool of Engineering, The University of TokyoSchool of Engineering, The University of TokyoIn vitro and in vivo testing can provide insight into knee joint mechanics and implant performance. However, these methods are costly and time-consuming, which always limits their widespread use during the design stage of the implant. This review presents a critical analysis of computational modelling (in-silicon) techniques including (i) development of a generic model of total knee replacement (TKR) and application of material properties, loading, and boundary conditions; (ii) design and execution of computational experiments; and (iii) practical applications and significant findings. The results show that the generic model and techniques provide significant insight into the general performance of TKR but have limited explicit validation. The introduction of design-of-experiments, probabilistic, and neural network methodologies in computational modelling has enabled simulation at the population level. Further advances in subjective modelling appear to be limited, mainly because of the lack of subjective materials and boundary conditions. Computational modelling will increasingly be used in the preclinical testing and design of TKR. This modelling should include subjective, multi-scale, and closely corroborated analyses to account for the variability of TKR.https://digital-library.theiet.org/content/journals/10.1049/bsbt.2019.0012boneneural netsbiomechanicsorthopaedicsprostheticsmedical computingreviewsdesign of experimentsprobabilitysystematic reviewcomputational modellingbiomechanics analysistotal knee replacementknee joint mechanicsimplant performancedesign stageboundary conditionscomputational experimentsdesign-of-experimentssubjective modellingpreclinical testingin vivo testingin vitro testingmaterial propertiesprobabilistic methodologyneural network methodology
spellingShingle Liming Shu
Shihao Li
Shihao Li
Naohiko Sugita
Systematic review of computational modelling for biomechanics analysis of total knee replacement
Biosurface and Biotribology
bone
neural nets
biomechanics
orthopaedics
prosthetics
medical computing
reviews
design of experiments
probability
systematic review
computational modelling
biomechanics analysis
total knee replacement
knee joint mechanics
implant performance
design stage
boundary conditions
computational experiments
design-of-experiments
subjective modelling
preclinical testing
in vivo testing
in vitro testing
material properties
probabilistic methodology
neural network methodology
title Systematic review of computational modelling for biomechanics analysis of total knee replacement
title_full Systematic review of computational modelling for biomechanics analysis of total knee replacement
title_fullStr Systematic review of computational modelling for biomechanics analysis of total knee replacement
title_full_unstemmed Systematic review of computational modelling for biomechanics analysis of total knee replacement
title_short Systematic review of computational modelling for biomechanics analysis of total knee replacement
title_sort systematic review of computational modelling for biomechanics analysis of total knee replacement
topic bone
neural nets
biomechanics
orthopaedics
prosthetics
medical computing
reviews
design of experiments
probability
systematic review
computational modelling
biomechanics analysis
total knee replacement
knee joint mechanics
implant performance
design stage
boundary conditions
computational experiments
design-of-experiments
subjective modelling
preclinical testing
in vivo testing
in vitro testing
material properties
probabilistic methodology
neural network methodology
url https://digital-library.theiet.org/content/journals/10.1049/bsbt.2019.0012
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