Is Mesenteric Panniculitis a Sign for Autoimmune Diabetes in Adults?
ABSTRACT: Objective: Mesenteric panniculitis (MP) and sclerosing mesenteritis is an umbrella term used to describe a rare, chronic, and frequently benign fibrosing inflammatory disease that affects the adipose tissue of the mesentery. The diagnosis is usually based on imaging (computed tomography &a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | AACE Clinical Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2376060520303941 |
| _version_ | 1818950122152656896 |
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| author | Evangelos C. Rizos, MD, PhD Thalia Panagiotopoulou, MD Evangelos Liberopoulos, MD, PhD Moses Elisaf, MD, PhD Athina Tsili, MD, PhD Maria I. Argyropoulou, MD, PhD Stelios K. Tigas, MD, PhD |
| author_facet | Evangelos C. Rizos, MD, PhD Thalia Panagiotopoulou, MD Evangelos Liberopoulos, MD, PhD Moses Elisaf, MD, PhD Athina Tsili, MD, PhD Maria I. Argyropoulou, MD, PhD Stelios K. Tigas, MD, PhD |
| author_sort | Evangelos C. Rizos, MD, PhD |
| collection | DOAJ |
| description | ABSTRACT: Objective: Mesenteric panniculitis (MP) and sclerosing mesenteritis is an umbrella term used to describe a rare, chronic, and frequently benign fibrosing inflammatory disease that affects the adipose tissue of the mesentery. The diagnosis is usually based on imaging (computed tomography [CT] or magnetic resonance imaging) findings and is confirmed by biopsy. We report the unusual case of a patient with MP with typical CT findings and diabetes mellitus (DM).Methods: A 48-year-old male presented for symptomatic new onset DM. An abdominal CT scan revealed a well-defined mesenteric mass compatible with MP. The combination of insulin degludec and sitagliptin/metformin resulted in a decrease of HbA1c; however, this was followed by a subsequent gradual increase in HbA1c and positive glutamic acid decarboxylase auto-antibodies.Results: The patient developed auto-immune DM that was confirmed by the presence of auto-antibodies.Conclusion: Panniculitis has been infrequently reported in patients with type 2 DM. This is the first report of a patient with MP correlated with auto-immune DM. The possible pathophysiologic mechanisms are discussed.Abbreviations: CT computed tomography DM diabetes mellitus HbA1c hemoglobin A1c MP mesenteric panniculitis SM sclerosing mesenteritis |
| first_indexed | 2024-12-20T09:13:34Z |
| format | Article |
| id | doaj.art-a79d8cc839ac4a468db36daca4309093 |
| institution | Directory Open Access Journal |
| issn | 2376-0605 |
| language | English |
| last_indexed | 2024-12-20T09:13:34Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AACE Clinical Case Reports |
| spelling | doaj.art-a79d8cc839ac4a468db36daca43090932022-12-21T19:45:28ZengElsevierAACE Clinical Case Reports2376-06052019-05-0153e181e183Is Mesenteric Panniculitis a Sign for Autoimmune Diabetes in Adults?Evangelos C. Rizos, MD, PhD0Thalia Panagiotopoulou, MD1Evangelos Liberopoulos, MD, PhD2Moses Elisaf, MD, PhD3Athina Tsili, MD, PhD4Maria I. Argyropoulou, MD, PhD5Stelios K. Tigas, MD, PhD6Internal Medicine Department, University Hospital of Ioannina, Ioannina, Greece; European University Cyprus School of Medicine, Nicosia, Cyprus; Address correspondence to Dr. Evangelos C. Rizos, Consultant in Internal Medicine, Diabetologist, Department of Internal Medicine, University Hospital of Ioannina, Greece, Leof Street, Niarchou, Ioannina 45500, Greece.Internal Medicine Department, University Hospital of Ioannina, Ioannina, GreeceInternal Medicine Department, University Hospital of Ioannina, Ioannina, GreeceInternal Medicine Department, University Hospital of Ioannina, Ioannina, GreeceClinical Radiology Department, University Hospital of Ioannina, Ioannina, GreeceClinical Radiology Department, University Hospital of Ioannina, Ioannina, GreeceEndocrinology Department, University Hospital of Ioannina, Ioannina, Greece.ABSTRACT: Objective: Mesenteric panniculitis (MP) and sclerosing mesenteritis is an umbrella term used to describe a rare, chronic, and frequently benign fibrosing inflammatory disease that affects the adipose tissue of the mesentery. The diagnosis is usually based on imaging (computed tomography [CT] or magnetic resonance imaging) findings and is confirmed by biopsy. We report the unusual case of a patient with MP with typical CT findings and diabetes mellitus (DM).Methods: A 48-year-old male presented for symptomatic new onset DM. An abdominal CT scan revealed a well-defined mesenteric mass compatible with MP. The combination of insulin degludec and sitagliptin/metformin resulted in a decrease of HbA1c; however, this was followed by a subsequent gradual increase in HbA1c and positive glutamic acid decarboxylase auto-antibodies.Results: The patient developed auto-immune DM that was confirmed by the presence of auto-antibodies.Conclusion: Panniculitis has been infrequently reported in patients with type 2 DM. This is the first report of a patient with MP correlated with auto-immune DM. The possible pathophysiologic mechanisms are discussed.Abbreviations: CT computed tomography DM diabetes mellitus HbA1c hemoglobin A1c MP mesenteric panniculitis SM sclerosing mesenteritishttp://www.sciencedirect.com/science/article/pii/S2376060520303941 |
| spellingShingle | Evangelos C. Rizos, MD, PhD Thalia Panagiotopoulou, MD Evangelos Liberopoulos, MD, PhD Moses Elisaf, MD, PhD Athina Tsili, MD, PhD Maria I. Argyropoulou, MD, PhD Stelios K. Tigas, MD, PhD Is Mesenteric Panniculitis a Sign for Autoimmune Diabetes in Adults? AACE Clinical Case Reports |
| title | Is Mesenteric Panniculitis a Sign for Autoimmune Diabetes in Adults? |
| title_full | Is Mesenteric Panniculitis a Sign for Autoimmune Diabetes in Adults? |
| title_fullStr | Is Mesenteric Panniculitis a Sign for Autoimmune Diabetes in Adults? |
| title_full_unstemmed | Is Mesenteric Panniculitis a Sign for Autoimmune Diabetes in Adults? |
| title_short | Is Mesenteric Panniculitis a Sign for Autoimmune Diabetes in Adults? |
| title_sort | is mesenteric panniculitis a sign for autoimmune diabetes in adults |
| url | http://www.sciencedirect.com/science/article/pii/S2376060520303941 |
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