Smaller anterior hippocampal subfields in the early stage of psychosis
Abstract Hippocampal volume is smaller in schizophrenia, but it is unclear when in the illness the changes appear and whether specific regions (anterior, posterior) and subfields (CA1, CA2/3, dentate gyrus, subiculum) are affected. Here, we used a high-resolution T2-weighted sequence specialized for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-01-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-023-02719-5 |
| _version_ | 1797273117502996480 |
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| author | Maureen McHugo Maxwell J. Roeske Simon N. Vandekar Kristan Armstrong Suzanne N. Avery Stephan Heckers |
| author_facet | Maureen McHugo Maxwell J. Roeske Simon N. Vandekar Kristan Armstrong Suzanne N. Avery Stephan Heckers |
| author_sort | Maureen McHugo |
| collection | DOAJ |
| description | Abstract Hippocampal volume is smaller in schizophrenia, but it is unclear when in the illness the changes appear and whether specific regions (anterior, posterior) and subfields (CA1, CA2/3, dentate gyrus, subiculum) are affected. Here, we used a high-resolution T2-weighted sequence specialized for imaging hippocampal subfields to test the hypothesis that anterior CA1 volume is lower in early psychosis. We measured subfield volumes across hippocampal regions in a group of 90 individuals in the early stage of a non-affective psychotic disorder and 70 demographically similar healthy individuals. We observed smaller volume in the anterior CA1 and dentate gyrus subfields in the early psychosis group. Our findings support models that implicate anterior CA1 and dentate gyrus subfield deficits in the mechanism of psychosis. |
| first_indexed | 2024-03-07T14:40:00Z |
| format | Article |
| id | doaj.art-a79ed7caa4b5491280bb938a50fdd48b |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-03-07T14:40:00Z |
| publishDate | 2024-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-a79ed7caa4b5491280bb938a50fdd48b2024-03-05T20:26:28ZengNature Publishing GroupTranslational Psychiatry2158-31882024-01-011411810.1038/s41398-023-02719-5Smaller anterior hippocampal subfields in the early stage of psychosisMaureen McHugo0Maxwell J. Roeske1Simon N. Vandekar2Kristan Armstrong3Suzanne N. Avery4Stephan Heckers5Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical CenterDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical CenterDepartment of Biostatistics, Vanderbilt University Medical CenterDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical CenterDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical CenterDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical CenterAbstract Hippocampal volume is smaller in schizophrenia, but it is unclear when in the illness the changes appear and whether specific regions (anterior, posterior) and subfields (CA1, CA2/3, dentate gyrus, subiculum) are affected. Here, we used a high-resolution T2-weighted sequence specialized for imaging hippocampal subfields to test the hypothesis that anterior CA1 volume is lower in early psychosis. We measured subfield volumes across hippocampal regions in a group of 90 individuals in the early stage of a non-affective psychotic disorder and 70 demographically similar healthy individuals. We observed smaller volume in the anterior CA1 and dentate gyrus subfields in the early psychosis group. Our findings support models that implicate anterior CA1 and dentate gyrus subfield deficits in the mechanism of psychosis.https://doi.org/10.1038/s41398-023-02719-5 |
| spellingShingle | Maureen McHugo Maxwell J. Roeske Simon N. Vandekar Kristan Armstrong Suzanne N. Avery Stephan Heckers Smaller anterior hippocampal subfields in the early stage of psychosis Translational Psychiatry |
| title | Smaller anterior hippocampal subfields in the early stage of psychosis |
| title_full | Smaller anterior hippocampal subfields in the early stage of psychosis |
| title_fullStr | Smaller anterior hippocampal subfields in the early stage of psychosis |
| title_full_unstemmed | Smaller anterior hippocampal subfields in the early stage of psychosis |
| title_short | Smaller anterior hippocampal subfields in the early stage of psychosis |
| title_sort | smaller anterior hippocampal subfields in the early stage of psychosis |
| url | https://doi.org/10.1038/s41398-023-02719-5 |
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