The prostaglandin E2/EP4 receptor/cyclic AMP/T-type Ca2+ channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells

The prostaglandin E2/EP4 receptor/cyclic AMP/T-type Ca2+ channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells

We investigated mechanisms for the neuritogenesis caused by prostaglandin E2 (PGE2) or intracellular cyclic AMP (cAMP) in sensory neuron-like ND7/23 cells. PGE2 caused neuritogenesis, an effect abolished by an EP4 receptor antagonist or inhibitors of adenylyl cyclase (AC) or protein kinase A (PKA) a...

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Bibliographic Details
Main Authors: Kenji Mitani, Fumiko Sekiguchi, Takashi Maeda, Yukari Tanaka, Shigeru Yoshida, Atsufumi Kawabata
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Journal of Pharmacological Sciences
Subjects:
T-type calcium channel
Neuritogenesis
Sensory neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316000293

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