Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension

Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension

Background: Imbalance between cell proliferation and apoptosis underlies the development of pulmonary arterial hypertension (PAH). Current vasodilator treatment of PAH does not target the uncontrolled proliferative process in pulmonary arteries. Proteins involved in the apoptosis pathway may play a...

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Bibliographic Details
Main Authors: Isabel Blanco, Maribel Marquina, Olga Tura-Ceide, Elisabet Ferrer, Ana M. Ramírez, Manuel Lopez-Meseguer, Maria Callejo, Francisco Perez-Vizcaino, Victor Ivo Peinado, Joan Albert Barberà
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary circulation
animal model
hypoxia
SU5416
YM155
pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1145994/full

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