High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in Thailand
Objectives: To investigate the seroprevalence of respiratory syncytial virus (RSV) infections in young children, the correlation between RSV antibody levels in maternal and cord serum, and to provide evidence of RSV reinfection in Thai children after primary infections. Methods: Serum samples were c...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222005793 |
| _version_ | 1797980831772311552 |
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| author | Siripat Pasittungkul Ilada Thongpan Preeyaporn Vichaiwattana Thanunrat Thongmee Sirapa Klinfueng Nungruthai Suntronwong Nasamon Wanlapakorn Sompong Vongpunsawad Yong Poovorawan |
| author_facet | Siripat Pasittungkul Ilada Thongpan Preeyaporn Vichaiwattana Thanunrat Thongmee Sirapa Klinfueng Nungruthai Suntronwong Nasamon Wanlapakorn Sompong Vongpunsawad Yong Poovorawan |
| author_sort | Siripat Pasittungkul |
| collection | DOAJ |
| description | Objectives: To investigate the seroprevalence of respiratory syncytial virus (RSV) infections in young children, the correlation between RSV antibody levels in maternal and cord serum, and to provide evidence of RSV reinfection in Thai children after primary infections. Methods: Serum samples were collected from 302 mothers and 291 children between 2015 and 2021. Maternal and cord blood were collected at birth. Serial serum samples of children were collected at the ages of 2, 7, 18, 19, 24, 36, 48, and 60 months and the presence of anti-RSV immunoglobulin G (IgG) was tested using an enzyme-linked immunosorbent assay. Results: The cord: maternal serum antibody ratio was 1.09 (95% confidence interval 1.08-1.11). Although >90% of babies at birth were seropositive through transplacental transfer, antibody levels gradually declined, with the highest seronegative rate (91.9%) at 7 months of age. Subsequently, anti-RSV IgG levels increased with age, most likely due to natural infection. One-third of the children showed evidence of reinfection as determined by seroconversion of anti-RSV IgG or increased titers of at least 50 relative units/ml. Conclusion: Waning of RSV antibodies in infants is rapid, and RSV infection subsequently increases anti-RSV IgG titers. RSV vaccination in children before the age of 7 months should be recommended. |
| first_indexed | 2024-04-11T06:01:09Z |
| format | Article |
| id | doaj.art-a7a1157c10fe48409f3d59fa994a6719 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-11T06:01:09Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-a7a1157c10fe48409f3d59fa994a67192022-12-22T04:41:42ZengElsevierInternational Journal of Infectious Diseases1201-97122022-12-01125177183High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in ThailandSiripat Pasittungkul0Ilada Thongpan1Preeyaporn Vichaiwattana2Thanunrat Thongmee3Sirapa Klinfueng4Nungruthai Suntronwong5Nasamon Wanlapakorn6Sompong Vongpunsawad7Yong Poovorawan8Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, USACenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Corresponding author: Yong Poovorawan, Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.Objectives: To investigate the seroprevalence of respiratory syncytial virus (RSV) infections in young children, the correlation between RSV antibody levels in maternal and cord serum, and to provide evidence of RSV reinfection in Thai children after primary infections. Methods: Serum samples were collected from 302 mothers and 291 children between 2015 and 2021. Maternal and cord blood were collected at birth. Serial serum samples of children were collected at the ages of 2, 7, 18, 19, 24, 36, 48, and 60 months and the presence of anti-RSV immunoglobulin G (IgG) was tested using an enzyme-linked immunosorbent assay. Results: The cord: maternal serum antibody ratio was 1.09 (95% confidence interval 1.08-1.11). Although >90% of babies at birth were seropositive through transplacental transfer, antibody levels gradually declined, with the highest seronegative rate (91.9%) at 7 months of age. Subsequently, anti-RSV IgG levels increased with age, most likely due to natural infection. One-third of the children showed evidence of reinfection as determined by seroconversion of anti-RSV IgG or increased titers of at least 50 relative units/ml. Conclusion: Waning of RSV antibodies in infants is rapid, and RSV infection subsequently increases anti-RSV IgG titers. RSV vaccination in children before the age of 7 months should be recommended.http://www.sciencedirect.com/science/article/pii/S1201971222005793SeroprevalenceRSVReinfectionInfantsYoung children |
| spellingShingle | Siripat Pasittungkul Ilada Thongpan Preeyaporn Vichaiwattana Thanunrat Thongmee Sirapa Klinfueng Nungruthai Suntronwong Nasamon Wanlapakorn Sompong Vongpunsawad Yong Poovorawan High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in Thailand International Journal of Infectious Diseases Seroprevalence RSV Reinfection Infants Young children |
| title | High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in Thailand |
| title_full | High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in Thailand |
| title_fullStr | High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in Thailand |
| title_full_unstemmed | High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in Thailand |
| title_short | High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in Thailand |
| title_sort | high seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in thailand |
| topic | Seroprevalence RSV Reinfection Infants Young children |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222005793 |
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