Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort
Abstract Background Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the prognostic value of Programmed Death Ligand-1 (PD-L1) in a true population-ba...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-019-5345-6 |
| _version_ | 1828261172454883328 |
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| author | Ann C. Eriksen Flemming B. Sørensen Jan Lindebjerg Henrik Hager René dePont Christensen Sanne Kjær-Frifeldt Torben F. Hansen |
| author_facet | Ann C. Eriksen Flemming B. Sørensen Jan Lindebjerg Henrik Hager René dePont Christensen Sanne Kjær-Frifeldt Torben F. Hansen |
| author_sort | Ann C. Eriksen |
| collection | DOAJ |
| description | Abstract Background Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the prognostic value of Programmed Death Ligand-1 (PD-L1) in a true population-based cohort of patients with stage II CC. Methods PD-L1 expression on tumour cells was evaluated by immunohistochemistry in 572 colon cancers. Whole sections from tumour blocks representing the deepest invasive front of the primary tumour were used for analysis. A cut-off of 5% positivity was used for dichotomizing the data. The prognostic value was investigated in Cox proportional hazard models for recurrence-free survival (RFS) and overall survival (OS). Results Overall, 6% of the tumours were classified as high PD-L1. High PD-L1 was related to female gender (p = 0.028), high malignancy grade (< 0.001), right side localization (p < 0.001) and microsatellite instability (MSI) (p < 0.001). Thirty-one (18%) of the MSI and 4 (1%) of the microsatellite stable tumours were classified as high PD-L1, respectively. PD-L1 expression provided no prognostic value as a single marker. In patients with MSI tumours, high PD-L1 expression had no significant impact regarding OS or RFS. Conclusions PD-L1 expression in tumour cells of stage II CC did not provide any prognostic impact, neither in the entire population-based cohort nor in the group of MSI patients. Additional investigations of the immunogenic microenvironment are needed for evaluating the prognostic information in CC. |
| first_indexed | 2024-04-13T03:34:02Z |
| format | Article |
| id | doaj.art-a7a28e1f0129481eac9dc83264f54523 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T03:34:02Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-a7a28e1f0129481eac9dc83264f545232022-12-22T03:04:22ZengBMCBMC Cancer1471-24072019-02-011911910.1186/s12885-019-5345-6Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohortAnn C. Eriksen0Flemming B. Sørensen1Jan Lindebjerg2Henrik Hager3René dePont Christensen4Sanne Kjær-Frifeldt5Torben F. Hansen6Danish Colorectal Cancer Center South, Vejle HospitalDanish Colorectal Cancer Center South, Vejle HospitalDanish Colorectal Cancer Center South, Vejle HospitalDanish Colorectal Cancer Center South, Vejle HospitalResearch Unit of General Practice, University of Southern DenmarkDanish Colorectal Cancer Center South, Vejle HospitalDanish Colorectal Cancer Center South, Vejle HospitalAbstract Background Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the prognostic value of Programmed Death Ligand-1 (PD-L1) in a true population-based cohort of patients with stage II CC. Methods PD-L1 expression on tumour cells was evaluated by immunohistochemistry in 572 colon cancers. Whole sections from tumour blocks representing the deepest invasive front of the primary tumour were used for analysis. A cut-off of 5% positivity was used for dichotomizing the data. The prognostic value was investigated in Cox proportional hazard models for recurrence-free survival (RFS) and overall survival (OS). Results Overall, 6% of the tumours were classified as high PD-L1. High PD-L1 was related to female gender (p = 0.028), high malignancy grade (< 0.001), right side localization (p < 0.001) and microsatellite instability (MSI) (p < 0.001). Thirty-one (18%) of the MSI and 4 (1%) of the microsatellite stable tumours were classified as high PD-L1, respectively. PD-L1 expression provided no prognostic value as a single marker. In patients with MSI tumours, high PD-L1 expression had no significant impact regarding OS or RFS. Conclusions PD-L1 expression in tumour cells of stage II CC did not provide any prognostic impact, neither in the entire population-based cohort nor in the group of MSI patients. Additional investigations of the immunogenic microenvironment are needed for evaluating the prognostic information in CC.http://link.springer.com/article/10.1186/s12885-019-5345-6Colon cancer stage IIPrognostic markersProgrammed death ligand-1 |
| spellingShingle | Ann C. Eriksen Flemming B. Sørensen Jan Lindebjerg Henrik Hager René dePont Christensen Sanne Kjær-Frifeldt Torben F. Hansen Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort BMC Cancer Colon cancer stage II Prognostic markers Programmed death ligand-1 |
| title | Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort |
| title_full | Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort |
| title_fullStr | Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort |
| title_full_unstemmed | Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort |
| title_short | Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort |
| title_sort | programmed death ligand 1 expression in stage ii colon cancer experiences from a nationwide populationbased cohort |
| topic | Colon cancer stage II Prognostic markers Programmed death ligand-1 |
| url | http://link.springer.com/article/10.1186/s12885-019-5345-6 |
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