A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies

A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies

Abstract Background Multilocus analysis on a set of single nucleotide polymorphisms (SNPs) pre-assigned within a gene constitutes a valuable complement to single-marker analysis by aggregating data on complex traits in a biologically meaningful way. However, despite the existence of a wide variety o...

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Bibliographic Details
Main Authors: Zhonghe Shao, Ting Wang, Jiahao Qiao, Yuchen Zhang, Shuiping Huang, Ping Zeng
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Bioinformatics
Subjects:
Genome-wide association study
Multilocus method
SNP-set analysis
Summary statistics
P value combination method
Common and rare variant association study
Online Access:https://doi.org/10.1186/s12859-022-04897-3

Internet

https://doi.org/10.1186/s12859-022-04897-3

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