A genome-wide survey of changes in protein evolutionary rates across four closely related species of <it>Saccharomyces </it>sensu stricto group
<p>Abstract</p> <p>Background</p> <p>Changes in protein evolutionary rates among lineages have been frequently observed during periods of notable phenotypic evolution. It is also known that, following gene duplication and loss, the protein evolutionary rates of genes in...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-01-01
|
| Series: | BMC Evolutionary Biology |
| Online Access: | http://www.biomedcentral.com/1471-2148/7/9 |
| _version_ | 1818775646299488256 |
|---|---|
| author | Imanishi Tadashi Kawahara Yoshihiro |
| author_facet | Imanishi Tadashi Kawahara Yoshihiro |
| author_sort | Imanishi Tadashi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Changes in protein evolutionary rates among lineages have been frequently observed during periods of notable phenotypic evolution. It is also known that, following gene duplication and loss, the protein evolutionary rates of genes involved in such events changed because of changes in functional constraints acting on the genes. However, in the evolution of closely related species, excluding the aforementioned situations, the frequency of changes in protein evolutionary rates is still not clear at the genome-wide level. Here we examine the constancy of protein evolutionary rates in the evolution of four closely related species of the <it>Saccharomyces </it>sensu stricto group (<it>S. cerevisiae</it>, <it>S. paradoxus</it>, <it>S. mikatae </it>and <it>S. bayanus</it>).</p> <p>Results</p> <p>For 2,610 unambiguously defined orthologous genes among the four species, we carried out likelihood ratio tests between constant-rate and variable-rate models and found 344 (13.2%) genes showing significant changes in the protein evolutionary rates in at least one lineage. Of all those genes which experienced rate changes, 139 and 49 genes showed accelerated and decelerated evolution, respectively. Most of the evolutionary rate changes could be attributed to changes in selective constraints acting on nonsynonymous sites, independently of species-specific gene duplication and loss. We estimated that the changes in protein evolutionary rates have appeared with a probability of 2.0 × 10<sup>-3 </sup>per gene per million years in the evolution of the <it>Saccharomyces </it>species. Furthermore, we found that the genes which experienced rate acceleration have lower expression levels and weaker codon usage bias than those which experienced rate deceleration.</p> <p>Conclusion</p> <p>Changes in protein evolutionary rates possibly occur frequently in the evolution of closely related <it>Saccharomyces </it>species. Selection for translational accuracy and efficiency may dominantly affect the variability of protein evolutionary rates.</p> |
| first_indexed | 2024-12-18T11:00:21Z |
| format | Article |
| id | doaj.art-a7a3384e83824f0e908b1baa4f4ad5f8 |
| institution | Directory Open Access Journal |
| issn | 1471-2148 |
| language | English |
| last_indexed | 2024-12-18T11:00:21Z |
| publishDate | 2007-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Evolutionary Biology |
| spelling | doaj.art-a7a3384e83824f0e908b1baa4f4ad5f82022-12-21T21:10:13ZengBMCBMC Evolutionary Biology1471-21482007-01-0171910.1186/1471-2148-7-9A genome-wide survey of changes in protein evolutionary rates across four closely related species of <it>Saccharomyces </it>sensu stricto groupImanishi TadashiKawahara Yoshihiro<p>Abstract</p> <p>Background</p> <p>Changes in protein evolutionary rates among lineages have been frequently observed during periods of notable phenotypic evolution. It is also known that, following gene duplication and loss, the protein evolutionary rates of genes involved in such events changed because of changes in functional constraints acting on the genes. However, in the evolution of closely related species, excluding the aforementioned situations, the frequency of changes in protein evolutionary rates is still not clear at the genome-wide level. Here we examine the constancy of protein evolutionary rates in the evolution of four closely related species of the <it>Saccharomyces </it>sensu stricto group (<it>S. cerevisiae</it>, <it>S. paradoxus</it>, <it>S. mikatae </it>and <it>S. bayanus</it>).</p> <p>Results</p> <p>For 2,610 unambiguously defined orthologous genes among the four species, we carried out likelihood ratio tests between constant-rate and variable-rate models and found 344 (13.2%) genes showing significant changes in the protein evolutionary rates in at least one lineage. Of all those genes which experienced rate changes, 139 and 49 genes showed accelerated and decelerated evolution, respectively. Most of the evolutionary rate changes could be attributed to changes in selective constraints acting on nonsynonymous sites, independently of species-specific gene duplication and loss. We estimated that the changes in protein evolutionary rates have appeared with a probability of 2.0 × 10<sup>-3 </sup>per gene per million years in the evolution of the <it>Saccharomyces </it>species. Furthermore, we found that the genes which experienced rate acceleration have lower expression levels and weaker codon usage bias than those which experienced rate deceleration.</p> <p>Conclusion</p> <p>Changes in protein evolutionary rates possibly occur frequently in the evolution of closely related <it>Saccharomyces </it>species. Selection for translational accuracy and efficiency may dominantly affect the variability of protein evolutionary rates.</p>http://www.biomedcentral.com/1471-2148/7/9 |
| spellingShingle | Imanishi Tadashi Kawahara Yoshihiro A genome-wide survey of changes in protein evolutionary rates across four closely related species of <it>Saccharomyces </it>sensu stricto group BMC Evolutionary Biology |
| title | A genome-wide survey of changes in protein evolutionary rates across four closely related species of <it>Saccharomyces </it>sensu stricto group |
| title_full | A genome-wide survey of changes in protein evolutionary rates across four closely related species of <it>Saccharomyces </it>sensu stricto group |
| title_fullStr | A genome-wide survey of changes in protein evolutionary rates across four closely related species of <it>Saccharomyces </it>sensu stricto group |
| title_full_unstemmed | A genome-wide survey of changes in protein evolutionary rates across four closely related species of <it>Saccharomyces </it>sensu stricto group |
| title_short | A genome-wide survey of changes in protein evolutionary rates across four closely related species of <it>Saccharomyces </it>sensu stricto group |
| title_sort | genome wide survey of changes in protein evolutionary rates across four closely related species of it saccharomyces it sensu stricto group |
| url | http://www.biomedcentral.com/1471-2148/7/9 |
| work_keys_str_mv | AT imanishitadashi agenomewidesurveyofchangesinproteinevolutionaryratesacrossfourcloselyrelatedspeciesofitsaccharomycesitsensustrictogroup AT kawaharayoshihiro agenomewidesurveyofchangesinproteinevolutionaryratesacrossfourcloselyrelatedspeciesofitsaccharomycesitsensustrictogroup AT imanishitadashi genomewidesurveyofchangesinproteinevolutionaryratesacrossfourcloselyrelatedspeciesofitsaccharomycesitsensustrictogroup AT kawaharayoshihiro genomewidesurveyofchangesinproteinevolutionaryratesacrossfourcloselyrelatedspeciesofitsaccharomycesitsensustrictogroup |