Evaluation of the EPR Effect in the CAM-Model by Molecular Imaging with MRI and PET Using <sup>89</sup>Zr-Labeled HSA

Evaluation of the EPR Effect in the CAM-Model by Molecular Imaging with MRI and PET Using <sup>89</sup>Zr-Labeled HSA

Mouse models are commonly used to study the biodistribution of novel radioligands, but alternative models corresponding to the 3Rs principles, such as the chorioallantoic membrane (CAM) model, are highly required. While there are promising data from the CAM model regarding target-specific radiolabel...

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Bibliographic Details
Main Authors: Colmar Hilbrig, Jessica Löffler, Gabriel Fischer, Ellen Scheidhauer, Christoph Solbach, Markus Huber-Lang, Ambros J. Beer, Volker Rasche, Gordon Winter
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
CAM model
CAM
chick embryo
PET
MRI
barrier defects
Online Access:https://www.mdpi.com/2072-6694/15/4/1126

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