Pediatric Stroke from Bench to Bedside: A Single-Center Experience in Saudi Arabia
Abdulaziz Mohammad Al-Sharydah,1 Hussain Khalid Al-Arfaj,2 Sari Saleh Al-Suhibani,1 Fahad Safran Al-Safran,2 Abdulrahman Hamad Al-Abdulwahhab,1 Saeed Ahmad Al-Jubran,1 Abdulhadi Ahmad AlSaflan3 1Diagnostic and Interventional Radiology Department, Imam Abdulrahman Bin Faisal University, King Fahd Hos...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-07-01
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| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/pediatric-stroke-from-bench-to-bedside-a-single-center-experience-in-s-peer-reviewed-fulltext-article-VHRM |
| _version_ | 1811225903829614592 |
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| author | Al-Sharydah AM Al-Arfaj HK Al-Suhibani SS Al-Safran FS Al-Abdulwahhab AH Al-Jubran SA AlSaflan AA |
| author_facet | Al-Sharydah AM Al-Arfaj HK Al-Suhibani SS Al-Safran FS Al-Abdulwahhab AH Al-Jubran SA AlSaflan AA |
| author_sort | Al-Sharydah AM |
| collection | DOAJ |
| description | Abdulaziz Mohammad Al-Sharydah,1 Hussain Khalid Al-Arfaj,2 Sari Saleh Al-Suhibani,1 Fahad Safran Al-Safran,2 Abdulrahman Hamad Al-Abdulwahhab,1 Saeed Ahmad Al-Jubran,1 Abdulhadi Ahmad AlSaflan3 1Diagnostic and Interventional Radiology Department, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Khobar City, Eastern Province, Saudi Arabia; 2Medical Imaging Department, King Fahd Specialist Hospital, Dammam City, Eastern Province, Saudi Arabia; 3Anesthesia Department, King Fahd Hospital of the University, Khobar City, Eastern Province, Saudi ArabiaCorrespondence: Abdulaziz Mohammad Al-Sharydah, Diagnostic and Interventional Radiology Department, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, P.O. Box: 31952 (4398), Khobar City, Eastern Province, Saudi Arabia, Tel +966 566473111, Fax +966 13-8676697, Email Amsharydah@iau.edu.saPurpose: Stroke is a leading cause of severe long-term disability and death worldwide. This study aimed to determine the genetic background, causative factors, and diagnostic and outcome measures of pediatric stroke in an area endemic to sickle cell disease (SCD).Patients and Methods: This retrospective review analyzed pediatric patients with acute stroke who were admitted to King Fahd Hospital of the University, Eastern Province, Saudi Arabia, between January and June 2019. We assessed 49 cases based on computed tomography (CT) and magnetic resonance imaging (MRI) findings. Patients with incomplete records or unavailable radiological images were excluded.Results: A high likelihood of familial coexistence of stroke was detected in patients with affected siblings (33%). Among various central nervous system manifestations, motor weakness (28.6%) and headache (20.4%) were the most common symptoms/signs. Hypoxic-ischemic encephalopathy (HIE) (28.6%), SCD (22.5%), and moyamoya disease (14.3%) were the most prevalent underlying etiologies. CT without intravenous contrast was the most used initial imaging technique (92.5%). An arterial blockage was more prevalent (53.4%) than a venous infarct (46.6%) (p = 0.041), while arterial ischemic stroke was more prevalent (56.5%) than hemorrhagic stroke (43.5%). The middle cerebral artery (MCA) was most affected (63.5%), followed by the anterior cerebral artery (22.7%) and posterior cerebral artery (13.6%). Most patients were managed with medical treatment (86.1%). No mortalities occurred during the initial hospital stay. The mean length of hospital stay was 12 days.Conclusion: HIE was the most prevalent etiology of pediatric stroke. Motor weakness and headache were the most common initial manifestations. Arterial ischemic stroke was more prevalent than venous or hemorrhagic stroke. Considering the rarity of pediatric stroke, future studies should be performed with a aborative effort nationally and internationally.Keywords: magnetic resonance imaging, computed tomography, ischemic stroke, hemorrhagic stroke, paediatric |
| first_indexed | 2024-04-12T09:15:10Z |
| format | Article |
| id | doaj.art-a7a4695b09954cad919170c581d95cd6 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-04-12T09:15:10Z |
| publishDate | 2022-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-a7a4695b09954cad919170c581d95cd62022-12-22T03:38:52ZengDove Medical PressVascular Health and Risk Management1178-20482022-07-01Volume 1852954076532Pediatric Stroke from Bench to Bedside: A Single-Center Experience in Saudi ArabiaAl-Sharydah AMAl-Arfaj HKAl-Suhibani SSAl-Safran FSAl-Abdulwahhab AHAl-Jubran SAAlSaflan AAAbdulaziz Mohammad Al-Sharydah,1 Hussain Khalid Al-Arfaj,2 Sari Saleh Al-Suhibani,1 Fahad Safran Al-Safran,2 Abdulrahman Hamad Al-Abdulwahhab,1 Saeed Ahmad Al-Jubran,1 Abdulhadi Ahmad AlSaflan3 1Diagnostic and Interventional Radiology Department, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Khobar City, Eastern Province, Saudi Arabia; 2Medical Imaging Department, King Fahd Specialist Hospital, Dammam City, Eastern Province, Saudi Arabia; 3Anesthesia Department, King Fahd Hospital of the University, Khobar City, Eastern Province, Saudi ArabiaCorrespondence: Abdulaziz Mohammad Al-Sharydah, Diagnostic and Interventional Radiology Department, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, P.O. Box: 31952 (4398), Khobar City, Eastern Province, Saudi Arabia, Tel +966 566473111, Fax +966 13-8676697, Email Amsharydah@iau.edu.saPurpose: Stroke is a leading cause of severe long-term disability and death worldwide. This study aimed to determine the genetic background, causative factors, and diagnostic and outcome measures of pediatric stroke in an area endemic to sickle cell disease (SCD).Patients and Methods: This retrospective review analyzed pediatric patients with acute stroke who were admitted to King Fahd Hospital of the University, Eastern Province, Saudi Arabia, between January and June 2019. We assessed 49 cases based on computed tomography (CT) and magnetic resonance imaging (MRI) findings. Patients with incomplete records or unavailable radiological images were excluded.Results: A high likelihood of familial coexistence of stroke was detected in patients with affected siblings (33%). Among various central nervous system manifestations, motor weakness (28.6%) and headache (20.4%) were the most common symptoms/signs. Hypoxic-ischemic encephalopathy (HIE) (28.6%), SCD (22.5%), and moyamoya disease (14.3%) were the most prevalent underlying etiologies. CT without intravenous contrast was the most used initial imaging technique (92.5%). An arterial blockage was more prevalent (53.4%) than a venous infarct (46.6%) (p = 0.041), while arterial ischemic stroke was more prevalent (56.5%) than hemorrhagic stroke (43.5%). The middle cerebral artery (MCA) was most affected (63.5%), followed by the anterior cerebral artery (22.7%) and posterior cerebral artery (13.6%). Most patients were managed with medical treatment (86.1%). No mortalities occurred during the initial hospital stay. The mean length of hospital stay was 12 days.Conclusion: HIE was the most prevalent etiology of pediatric stroke. Motor weakness and headache were the most common initial manifestations. Arterial ischemic stroke was more prevalent than venous or hemorrhagic stroke. Considering the rarity of pediatric stroke, future studies should be performed with a aborative effort nationally and internationally.Keywords: magnetic resonance imaging, computed tomography, ischemic stroke, hemorrhagic stroke, paediatrichttps://www.dovepress.com/pediatric-stroke-from-bench-to-bedside-a-single-center-experience-in-s-peer-reviewed-fulltext-article-VHRMmagnetic resonance imagingcomputed tomographyischemic strokehemorrhagic strokepaediatric |
| spellingShingle | Al-Sharydah AM Al-Arfaj HK Al-Suhibani SS Al-Safran FS Al-Abdulwahhab AH Al-Jubran SA AlSaflan AA Pediatric Stroke from Bench to Bedside: A Single-Center Experience in Saudi Arabia Vascular Health and Risk Management magnetic resonance imaging computed tomography ischemic stroke hemorrhagic stroke paediatric |
| title | Pediatric Stroke from Bench to Bedside: A Single-Center Experience in Saudi Arabia |
| title_full | Pediatric Stroke from Bench to Bedside: A Single-Center Experience in Saudi Arabia |
| title_fullStr | Pediatric Stroke from Bench to Bedside: A Single-Center Experience in Saudi Arabia |
| title_full_unstemmed | Pediatric Stroke from Bench to Bedside: A Single-Center Experience in Saudi Arabia |
| title_short | Pediatric Stroke from Bench to Bedside: A Single-Center Experience in Saudi Arabia |
| title_sort | pediatric stroke from bench to bedside a single center experience in saudi arabia |
| topic | magnetic resonance imaging computed tomography ischemic stroke hemorrhagic stroke paediatric |
| url | https://www.dovepress.com/pediatric-stroke-from-bench-to-bedside-a-single-center-experience-in-s-peer-reviewed-fulltext-article-VHRM |
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