Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications?
In recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby stopping or slowing cancer growth. Hormone treat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/3/759 |
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| author | Saikat Mitra Mashia Subha Lami Avoy Ghosh Rajib Das Trina Ekawati Tallei Fatimawali Fahadul Islam Kuldeep Dhama M. Yasmin Begum Afaf Aldahish Kumarappan Chidambaram Talha Bin Emran |
| author_facet | Saikat Mitra Mashia Subha Lami Avoy Ghosh Rajib Das Trina Ekawati Tallei Fatimawali Fahadul Islam Kuldeep Dhama M. Yasmin Begum Afaf Aldahish Kumarappan Chidambaram Talha Bin Emran |
| author_sort | Saikat Mitra |
| collection | DOAJ |
| description | In recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby stopping or slowing cancer growth. Hormone treatment works by preventing hormones from causing cancer cells to multiply. Aromatase inhibitors, anti-estrogens, progestin, estrogen receptor (ER) antagonists, GnRH agonists, and progestogen are effectively used as therapeutics for vulvar cancer, cervical cancer, vaginal cancer, uterine cancer, and ovarian cancer. Hormone replacement therapy has a high success rate. In particular, progestogen and estrogen replacement are associated with a decreased incidence of gynecological cancers in women infected with human papillomavirus (HPV). The activation of estrogen via the transcriptional functionality of ERα may either be promoted or decreased by gene products of HPV. Hormonal treatment is frequently administered to patients with hormone-sensitive recurring or metastatic gynecologic malignancies, although response rates and therapeutic outcomes are inconsistent. Therefore, this review outlines the use of hormonal therapy for gynecological cancers and identifies the current knowledge gaps. |
| first_indexed | 2024-03-10T00:06:31Z |
| format | Article |
| id | doaj.art-a7a56405f93644a68d5d588b233c1825 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:06:31Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a7a56405f93644a68d5d588b233c18252023-11-23T16:08:10ZengMDPI AGCancers2072-66942022-02-0114375910.3390/cancers14030759Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications?Saikat Mitra0Mashia Subha Lami1Avoy Ghosh2Rajib Das3Trina Ekawati Tallei4Fatimawali5Fahadul Islam6Kuldeep Dhama7M. Yasmin Begum8Afaf Aldahish9Kumarappan Chidambaram10Talha Bin Emran11Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado 95115, IndonesiaThe University Center of Excellence for Biotechnology and Conservation of Wallacea, Institute for Research and Community Services, Sam Ratulangi University, Manado 95115, IndonesiaDepartment of Pharmacy, Faculty of Allied Health of Sciences, Daffodil International University, Dhaka 1207, BangladeshDivision of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, IndiaDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 61441, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, BangladeshIn recent years, hormone therapy has been shown to be a remarkable treatment option for cancer. Hormone treatment for gynecological cancers involves the use of medications that reduce the level of hormones or inhibit their biological activity, thereby stopping or slowing cancer growth. Hormone treatment works by preventing hormones from causing cancer cells to multiply. Aromatase inhibitors, anti-estrogens, progestin, estrogen receptor (ER) antagonists, GnRH agonists, and progestogen are effectively used as therapeutics for vulvar cancer, cervical cancer, vaginal cancer, uterine cancer, and ovarian cancer. Hormone replacement therapy has a high success rate. In particular, progestogen and estrogen replacement are associated with a decreased incidence of gynecological cancers in women infected with human papillomavirus (HPV). The activation of estrogen via the transcriptional functionality of ERα may either be promoted or decreased by gene products of HPV. Hormonal treatment is frequently administered to patients with hormone-sensitive recurring or metastatic gynecologic malignancies, although response rates and therapeutic outcomes are inconsistent. Therefore, this review outlines the use of hormonal therapy for gynecological cancers and identifies the current knowledge gaps.https://www.mdpi.com/2072-6694/14/3/759hormonal therapygynecological cancersaromatase inhibitorsanti-estrogenGnRH agonist |
| spellingShingle | Saikat Mitra Mashia Subha Lami Avoy Ghosh Rajib Das Trina Ekawati Tallei Fatimawali Fahadul Islam Kuldeep Dhama M. Yasmin Begum Afaf Aldahish Kumarappan Chidambaram Talha Bin Emran Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications? Cancers hormonal therapy gynecological cancers aromatase inhibitors anti-estrogen GnRH agonist |
| title | Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications? |
| title_full | Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications? |
| title_fullStr | Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications? |
| title_full_unstemmed | Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications? |
| title_short | Hormonal Therapy for Gynecological Cancers: How Far Has Science Progressed toward Clinical Applications? |
| title_sort | hormonal therapy for gynecological cancers how far has science progressed toward clinical applications |
| topic | hormonal therapy gynecological cancers aromatase inhibitors anti-estrogen GnRH agonist |
| url | https://www.mdpi.com/2072-6694/14/3/759 |
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