Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis.
BACKGROUND: Previous studies on the association of X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp, Arg399Gln, and Arg280His polymorphisms with head and neck cancer (HNC) have produced inconsistent results. The aim of the present study was to evaluate the effects of these three polymorphi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3907446?pdf=render |
| _version_ | 1819213431231741952 |
|---|---|
| author | Wei Wu Lu Liu Zhihua Yin Peng Guan Xuelian Li Baosen Zhou |
| author_facet | Wei Wu Lu Liu Zhihua Yin Peng Guan Xuelian Li Baosen Zhou |
| author_sort | Wei Wu |
| collection | DOAJ |
| description | BACKGROUND: Previous studies on the association of X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp, Arg399Gln, and Arg280His polymorphisms with head and neck cancer (HNC) have produced inconsistent results. The aim of the present study was to evaluate the effects of these three polymorphic variants on HNC risk. METHODS: The PubMed and EMBASE databases were searched for genetic association studies on the XRCC1 Arg194Trp, Arg399Gln, and Arg280His polymorphisms and HNC risk. (The most recent search was conducted on 20 August, 2013.) Twenty-six studies were identified and meta-analysis was performed to evaluate the association between the polymorphism and HNC by calculating combined odds ratios and 95% confidence intervals. RESULTS: No significant association was found under the allelic, homozygous, heterozygote, and dominant genetic models in the overall comparison. Further, no significant association between the XRCC1 Arg399Gln and Arg280His polymorphisms and HNC risk was detected under the four genetic models in subgroup analyses based on ethnicity, cancer site, and whether or not the studies had been adjusted for cigarette smoking and alcohol. However, in stratified analyses based on cancer site, a significant association was found between the XRCC1 Arg194Trp polymorphism and oral cancer under the allelic, heterozygote, and dominant models. The XRCC1 Arg194Trp polymorphism was significantly associated with HNC risk in studies that were adjusted for smoking and alcohol under the homozygous and heterozygote models. CONCLUSION: The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site. Further studies with larger samples are needed to confirm these findings. |
| first_indexed | 2024-12-23T06:58:45Z |
| format | Article |
| id | doaj.art-a7a622eee9014f3c8c11259304a368fa |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T06:58:45Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a7a622eee9014f3c8c11259304a368fa2022-12-21T17:56:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8679810.1371/journal.pone.0086798Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis.Wei WuLu LiuZhihua YinPeng GuanXuelian LiBaosen ZhouBACKGROUND: Previous studies on the association of X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp, Arg399Gln, and Arg280His polymorphisms with head and neck cancer (HNC) have produced inconsistent results. The aim of the present study was to evaluate the effects of these three polymorphic variants on HNC risk. METHODS: The PubMed and EMBASE databases were searched for genetic association studies on the XRCC1 Arg194Trp, Arg399Gln, and Arg280His polymorphisms and HNC risk. (The most recent search was conducted on 20 August, 2013.) Twenty-six studies were identified and meta-analysis was performed to evaluate the association between the polymorphism and HNC by calculating combined odds ratios and 95% confidence intervals. RESULTS: No significant association was found under the allelic, homozygous, heterozygote, and dominant genetic models in the overall comparison. Further, no significant association between the XRCC1 Arg399Gln and Arg280His polymorphisms and HNC risk was detected under the four genetic models in subgroup analyses based on ethnicity, cancer site, and whether or not the studies had been adjusted for cigarette smoking and alcohol. However, in stratified analyses based on cancer site, a significant association was found between the XRCC1 Arg194Trp polymorphism and oral cancer under the allelic, heterozygote, and dominant models. The XRCC1 Arg194Trp polymorphism was significantly associated with HNC risk in studies that were adjusted for smoking and alcohol under the homozygous and heterozygote models. CONCLUSION: The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site. Further studies with larger samples are needed to confirm these findings.http://europepmc.org/articles/PMC3907446?pdf=render |
| spellingShingle | Wei Wu Lu Liu Zhihua Yin Peng Guan Xuelian Li Baosen Zhou Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis. PLoS ONE |
| title | Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis. |
| title_full | Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis. |
| title_fullStr | Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis. |
| title_full_unstemmed | Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis. |
| title_short | Association of X-ray repair cross-complementing group 1 Arg194Trp, Arg399Gln and Arg280His polymorphisms with head and neck cancer susceptibility: a meta-analysis. |
| title_sort | association of x ray repair cross complementing group 1 arg194trp arg399gln and arg280his polymorphisms with head and neck cancer susceptibility a meta analysis |
| url | http://europepmc.org/articles/PMC3907446?pdf=render |
| work_keys_str_mv | AT weiwu associationofxrayrepaircrosscomplementinggroup1arg194trparg399glnandarg280hispolymorphismswithheadandneckcancersusceptibilityametaanalysis AT luliu associationofxrayrepaircrosscomplementinggroup1arg194trparg399glnandarg280hispolymorphismswithheadandneckcancersusceptibilityametaanalysis AT zhihuayin associationofxrayrepaircrosscomplementinggroup1arg194trparg399glnandarg280hispolymorphismswithheadandneckcancersusceptibilityametaanalysis AT pengguan associationofxrayrepaircrosscomplementinggroup1arg194trparg399glnandarg280hispolymorphismswithheadandneckcancersusceptibilityametaanalysis AT xuelianli associationofxrayrepaircrosscomplementinggroup1arg194trparg399glnandarg280hispolymorphismswithheadandneckcancersusceptibilityametaanalysis AT baosenzhou associationofxrayrepaircrosscomplementinggroup1arg194trparg399glnandarg280hispolymorphismswithheadandneckcancersusceptibilityametaanalysis |