NLRP3 inflammasome and its inhibitors: a review
Inflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the complex belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and is also known as pyrin domain-co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00262/full |
| _version_ | 1818254116038639616 |
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| author | Bo-Zong eShao Zhe-qi eXu Bin-Ze eHan Ding-Feng eSu Chong eLiu |
| author_facet | Bo-Zong eShao Zhe-qi eXu Bin-Ze eHan Ding-Feng eSu Chong eLiu |
| author_sort | Bo-Zong eShao |
| collection | DOAJ |
| description | Inflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the complex belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and is also known as pyrin domain-containing protein 3. The NLRP3 inflammasome is associated with onset and progression of various diseases, including metabolic disorders, multiple sclerosis, inflammatory bowel disease, cryopyrin-associated periodic fever syndrome (CAPS), as well as other auto-immune and auto-inflammatory diseases. Several NLRP3 inflammasome inhibitors have been described, some of which show promise in the clinic. The present review will describe the structure and mechanisms of activation of the NLRP3 inflammasome, its association with various auto-immune and auto-inflammatory diseases, and the state of research into NLRP3 inflammasome inhibitors. |
| first_indexed | 2024-12-12T16:50:51Z |
| format | Article |
| id | doaj.art-a7a7697312ae4585b2dc7832ed8f4218 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T16:50:51Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a7a7697312ae4585b2dc7832ed8f42182022-12-22T00:18:23ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122015-11-01610.3389/fphar.2015.00262167682NLRP3 inflammasome and its inhibitors: a reviewBo-Zong eShao0Zhe-qi eXu1Bin-Ze eHan2Ding-Feng eSu3Chong eLiu4Second Military Medical UniversitySecond Military Medical UniversitySecond Military Medical UniversitySecond Military Medical UniversitySecond Military Medical UniversityInflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the complex belongs to the family of nucleotide-binding and oligomerization domain-like receptors (NLRs) and is also known as pyrin domain-containing protein 3. The NLRP3 inflammasome is associated with onset and progression of various diseases, including metabolic disorders, multiple sclerosis, inflammatory bowel disease, cryopyrin-associated periodic fever syndrome (CAPS), as well as other auto-immune and auto-inflammatory diseases. Several NLRP3 inflammasome inhibitors have been described, some of which show promise in the clinic. The present review will describe the structure and mechanisms of activation of the NLRP3 inflammasome, its association with various auto-immune and auto-inflammatory diseases, and the state of research into NLRP3 inflammasome inhibitors.http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00262/fullAutophagyinterferoninhibitorNLRP3 inflammasomeBHBMCC950 |
| spellingShingle | Bo-Zong eShao Zhe-qi eXu Bin-Ze eHan Ding-Feng eSu Chong eLiu NLRP3 inflammasome and its inhibitors: a review Frontiers in Pharmacology Autophagy interferon inhibitor NLRP3 inflammasome BHB MCC950 |
| title | NLRP3 inflammasome and its inhibitors: a review |
| title_full | NLRP3 inflammasome and its inhibitors: a review |
| title_fullStr | NLRP3 inflammasome and its inhibitors: a review |
| title_full_unstemmed | NLRP3 inflammasome and its inhibitors: a review |
| title_short | NLRP3 inflammasome and its inhibitors: a review |
| title_sort | nlrp3 inflammasome and its inhibitors a review |
| topic | Autophagy interferon inhibitor NLRP3 inflammasome BHB MCC950 |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00262/full |
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