Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from <i>Artemisia annua</i> L.
Artemisinin is an anti-malarial sesquiterpene lactone derived from <i>Artemisia annua</i> L. (Asteraceae family). One of the most widely used modes of treatment for malaria is an artemisinin-based combination therapy. Artemisinin and its associated compounds have a variety of pharmacolog...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/9/3040 |
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| author | Jameel M. Al-Khayri Wudali N. Sudheer Vasantha V. Lakshmaiah Epsita Mukherjee Aatika Nizam Muthu Thiruvengadam Praveen Nagella Fatima M. Alessa Muneera Q. Al-Mssallem Adel A. Rezk Wael F. Shehata Mahesh Attimarad |
| author_facet | Jameel M. Al-Khayri Wudali N. Sudheer Vasantha V. Lakshmaiah Epsita Mukherjee Aatika Nizam Muthu Thiruvengadam Praveen Nagella Fatima M. Alessa Muneera Q. Al-Mssallem Adel A. Rezk Wael F. Shehata Mahesh Attimarad |
| author_sort | Jameel M. Al-Khayri |
| collection | DOAJ |
| description | Artemisinin is an anti-malarial sesquiterpene lactone derived from <i>Artemisia annua</i> L. (Asteraceae family). One of the most widely used modes of treatment for malaria is an artemisinin-based combination therapy. Artemisinin and its associated compounds have a variety of pharmacological qualities that have helped achieve economic prominence in recent years. So far, research on the biosynthesis of this bioactive metabolite has revealed that it is produced in glandular trichomes and that the genes responsible for its production must be overexpressed in order to meet demand. Using biotechnological applications such as tissue culture, genetic engineering, and bioreactor-based approaches would aid in the upregulation of artemisinin yield, which is needed for the future. The current review focuses on the tissue culture aspects of propagation of <i>A. annua</i> and production of artemisinin from <i>A. annua</i> L. cell and organ cultures. The review also focuses on elicitation strategies in cell and organ cultures, as well as artemisinin biosynthesis and metabolic engineering of biosynthetic genes in <i>Artemisia</i> and plant model systems. |
| first_indexed | 2024-03-10T03:52:55Z |
| format | Article |
| id | doaj.art-a7a7a28fddab463fbafbcfd7cc06b354 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:52:55Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a7a7a28fddab463fbafbcfd7cc06b3542023-11-23T08:53:21ZengMDPI AGMolecules1420-30492022-05-01279304010.3390/molecules27093040Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from <i>Artemisia annua</i> L.Jameel M. Al-Khayri0Wudali N. Sudheer1Vasantha V. Lakshmaiah2Epsita Mukherjee3Aatika Nizam4Muthu Thiruvengadam5Praveen Nagella6Fatima M. Alessa7Muneera Q. Al-Mssallem8Adel A. Rezk9Wael F. Shehata10Mahesh Attimarad11Department of Plant Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Life Sciences, CHRIST (Deemed to be University), Bangalore 560029, IndiaDepartment of Life Sciences, CHRIST (Deemed to be University), Bangalore 560029, IndiaAmity Institute of Biotechnology, Amity University, Noida 201313, IndiaDepartment of Chemistry, CHRIST (Deemed to be University), Bangalore 560029, IndiaDepartment of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul 05029, KoreaDepartment of Life Sciences, CHRIST (Deemed to be University), Bangalore 560029, IndiaDepartment of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Food Science and Nutrition, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Plant Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Plant Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmacology, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaArtemisinin is an anti-malarial sesquiterpene lactone derived from <i>Artemisia annua</i> L. (Asteraceae family). One of the most widely used modes of treatment for malaria is an artemisinin-based combination therapy. Artemisinin and its associated compounds have a variety of pharmacological qualities that have helped achieve economic prominence in recent years. So far, research on the biosynthesis of this bioactive metabolite has revealed that it is produced in glandular trichomes and that the genes responsible for its production must be overexpressed in order to meet demand. Using biotechnological applications such as tissue culture, genetic engineering, and bioreactor-based approaches would aid in the upregulation of artemisinin yield, which is needed for the future. The current review focuses on the tissue culture aspects of propagation of <i>A. annua</i> and production of artemisinin from <i>A. annua</i> L. cell and organ cultures. The review also focuses on elicitation strategies in cell and organ cultures, as well as artemisinin biosynthesis and metabolic engineering of biosynthetic genes in <i>Artemisia</i> and plant model systems.https://www.mdpi.com/1420-3049/27/9/3040<i>Artemisia annua</i>Artemisinin<i>Agrobacterium rhizogenes</i>cell suspension cultureelicitationbioreactor |
| spellingShingle | Jameel M. Al-Khayri Wudali N. Sudheer Vasantha V. Lakshmaiah Epsita Mukherjee Aatika Nizam Muthu Thiruvengadam Praveen Nagella Fatima M. Alessa Muneera Q. Al-Mssallem Adel A. Rezk Wael F. Shehata Mahesh Attimarad Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from <i>Artemisia annua</i> L. Molecules <i>Artemisia annua</i> Artemisinin <i>Agrobacterium rhizogenes</i> cell suspension culture elicitation bioreactor |
| title | Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from <i>Artemisia annua</i> L. |
| title_full | Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from <i>Artemisia annua</i> L. |
| title_fullStr | Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from <i>Artemisia annua</i> L. |
| title_full_unstemmed | Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from <i>Artemisia annua</i> L. |
| title_short | Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from <i>Artemisia annua</i> L. |
| title_sort | biotechnological approaches for production of artemisinin an anti malarial drug from i artemisia annua i l |
| topic | <i>Artemisia annua</i> Artemisinin <i>Agrobacterium rhizogenes</i> cell suspension culture elicitation bioreactor |
| url | https://www.mdpi.com/1420-3049/27/9/3040 |
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